Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Polyphosphate (polyP) is a universally conserved molecule that plays critical roles in managing bacterial stress responses, in addition to biofilm formation and virulence. The enzymes that make polyphosphate molecules are called polyphosphate kinases (PPKs). Since these enzymes are not cons...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Kanchi Baijal, Michael Downey
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2021
Sujets:	PPK1 PPK2 Pseudomonas enzyme inhibition polyphosphate polyP Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/b800801f6c0743eb875df6e5a4e82236
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:b800801f6c0743eb875df6e5a4e82236
record_format	dspace
spelling	oai:doaj.org-article:b800801f6c0743eb875df6e5a4e822362021-11-10T18:37:52ZTargeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>10.1128/mBio.01477-212150-7511https://doaj.org/article/b800801f6c0743eb875df6e5a4e822362021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01477-21https://doaj.org/toc/2150-7511ABSTRACT Polyphosphate (polyP) is a universally conserved molecule that plays critical roles in managing bacterial stress responses, in addition to biofilm formation and virulence. The enzymes that make polyphosphate molecules are called polyphosphate kinases (PPKs). Since these enzymes are not conserved in higher eukaryotes, PPKs make excellent therapeutic targets. In a recent paper in mBio, Neville and colleagues described gallein, a commercially available G-protein antagonist, as a novel dual-specificity inhibitor against two families of PPK enzymes in Pseudomonas aeruginosa. In this commentary, we discuss the impact of this discovery, outline potential challenges of implementing gallein use in the clinic, and describe how gallein will serve as a fantastic new tool to further fundamental PPK and polyP research in bacteria.Kanchi BaijalMichael DowneyAmerican Society for MicrobiologyarticlePPK1PPK2Pseudomonasenzyme inhibitionpolyphosphatepolyPMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PPK1 PPK2 Pseudomonas enzyme inhibition polyphosphate polyP Microbiology QR1-502
spellingShingle	PPK1 PPK2 Pseudomonas enzyme inhibition polyphosphate polyP Microbiology QR1-502 Kanchi Baijal Michael Downey Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
description	ABSTRACT Polyphosphate (polyP) is a universally conserved molecule that plays critical roles in managing bacterial stress responses, in addition to biofilm formation and virulence. The enzymes that make polyphosphate molecules are called polyphosphate kinases (PPKs). Since these enzymes are not conserved in higher eukaryotes, PPKs make excellent therapeutic targets. In a recent paper in mBio, Neville and colleagues described gallein, a commercially available G-protein antagonist, as a novel dual-specificity inhibitor against two families of PPK enzymes in Pseudomonas aeruginosa. In this commentary, we discuss the impact of this discovery, outline potential challenges of implementing gallein use in the clinic, and describe how gallein will serve as a fantastic new tool to further fundamental PPK and polyP research in bacteria.
format	article
author	Kanchi Baijal Michael Downey
author_facet	Kanchi Baijal Michael Downey
author_sort	Kanchi Baijal
title	Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
title_short	Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
title_full	Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
title_fullStr	Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
title_full_unstemmed	Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
title_sort	targeting polyphosphate kinases in the fight against <named-content content-type="genus-species">pseudomonas aeruginosa</named-content>
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/b800801f6c0743eb875df6e5a4e82236
work_keys_str_mv	AT kanchibaijal targetingpolyphosphatekinasesinthefightagainstnamedcontentcontenttypegenusspeciespseudomonasaeruginosanamedcontent AT michaeldowney targetingpolyphosphatekinasesinthefightagainstnamedcontentcontenttypegenusspeciespseudomonasaeruginosanamedcontent
_version_	1718439808326434816

Targeting Polyphosphate Kinases in the Fight against <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

Documents similaires