Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health

Among the occupational and work-related diseases of employees in pharmaceutical industry the leading positions belong to the diseases caused by long-term work under the conditions of relatively low concentrations of hazard substances. The study and evaluation of risks will eliminate or reduce the im...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. G. Gorokhova, D. V. Surzhikov, N. N. Mikhailova, N. A. Martinova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	risk assessment human health benzodiazepine drugs Science Q
Acceso en línea:	https://doaj.org/article/b8008e66658e4fe8b6fb12ed4f68d72f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b8008e66658e4fe8b6fb12ed4f68d72f
record_format	dspace
spelling	oai:doaj.org-article:b8008e66658e4fe8b6fb12ed4f68d72f2021-11-23T06:14:27ZRisk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health2541-94202587-9596https://doaj.org/article/b8008e66658e4fe8b6fb12ed4f68d72f2013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1490https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Among the occupational and work-related diseases of employees in pharmaceutical industry the leading positions belong to the diseases caused by long-term work under the conditions of relatively low concentrations of hazard substances. The study and evaluation of risks will eliminate or reduce the impact, thereby, enhancing the quality of life. Synthetic drugs - benzodiazepine derivatives by the values of middle-lethal doses are substances of the 111 class of hazard and cause slight irritating effect to the skin and mucous membranes of the eyes; skin-resorptive and sensitizing effects have not been identified. For the studied benzodiazepine derivatives the safe exposure levels have been approved in the following values: nozepam -1 mg/m3; mezapam - 0.3 mg/m3; sibazon - 0.2 mg/m3; alprazolam - 0.1 mg/m3. On the base of the toxicological studies the parameters of the hazardous effects on the body have been identified allowing for a final risk characterization. The article presents the results of the calculation of the potential dose that may be received by the employee during the working shift in the synthesis of products of this series. Calculation of safe level of exposure is based on a threshold concentration of substances. Drags risk factors by inhalation have been calculated by comparing the value of the potential dose of a xenobiotic received for one shift by inhalation with its level of safe effect under the same route of exposure. The estimated hazard ratios for the studied substances demonstrate a low probability of adverse effects on the workers during the production of nozepam and alprazolam. High risk of negative impact on the health of workers has been identified during the production of sibazon and mezapam. This information can then be used to control the working environment during the synthesis of drugs - benzodiazepine derivatives, aimed at creating a safe working environment and, consequently, improving the workers' life quality.L. G. GorokhovaD. V. SurzhikovN. N. MikhailovaN. A. MartinovaScientific Сentre for Family Health and Human Reproduction Problemsarticlerisk assessmenthuman healthbenzodiazepine drugsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 57-59 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	risk assessment human health benzodiazepine drugs Science Q
spellingShingle	risk assessment human health benzodiazepine drugs Science Q L. G. Gorokhova D. V. Surzhikov N. N. Mikhailova N. A. Martinova Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
description	Among the occupational and work-related diseases of employees in pharmaceutical industry the leading positions belong to the diseases caused by long-term work under the conditions of relatively low concentrations of hazard substances. The study and evaluation of risks will eliminate or reduce the impact, thereby, enhancing the quality of life. Synthetic drugs - benzodiazepine derivatives by the values of middle-lethal doses are substances of the 111 class of hazard and cause slight irritating effect to the skin and mucous membranes of the eyes; skin-resorptive and sensitizing effects have not been identified. For the studied benzodiazepine derivatives the safe exposure levels have been approved in the following values: nozepam -1 mg/m3; mezapam - 0.3 mg/m3; sibazon - 0.2 mg/m3; alprazolam - 0.1 mg/m3. On the base of the toxicological studies the parameters of the hazardous effects on the body have been identified allowing for a final risk characterization. The article presents the results of the calculation of the potential dose that may be received by the employee during the working shift in the synthesis of products of this series. Calculation of safe level of exposure is based on a threshold concentration of substances. Drags risk factors by inhalation have been calculated by comparing the value of the potential dose of a xenobiotic received for one shift by inhalation with its level of safe effect under the same route of exposure. The estimated hazard ratios for the studied substances demonstrate a low probability of adverse effects on the workers during the production of nozepam and alprazolam. High risk of negative impact on the health of workers has been identified during the production of sibazon and mezapam. This information can then be used to control the working environment during the synthesis of drugs - benzodiazepine derivatives, aimed at creating a safe working environment and, consequently, improving the workers' life quality.
format	article
author	L. G. Gorokhova D. V. Surzhikov N. N. Mikhailova N. A. Martinova
author_facet	L. G. Gorokhova D. V. Surzhikov N. N. Mikhailova N. A. Martinova
author_sort	L. G. Gorokhova
title	Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
title_short	Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
title_full	Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
title_fullStr	Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
title_full_unstemmed	Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
title_sort	risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/b8008e66658e4fe8b6fb12ed4f68d72f
work_keys_str_mv	AT lggorokhova riskassessmentoftheadverseimpactofindustrialsynthesisofbenzodiazepinedrugsonhumanhealth AT dvsurzhikov riskassessmentoftheadverseimpactofindustrialsynthesisofbenzodiazepinedrugsonhumanhealth AT nnmikhailova riskassessmentoftheadverseimpactofindustrialsynthesisofbenzodiazepinedrugsonhumanhealth AT namartinova riskassessmentoftheadverseimpactofindustrialsynthesisofbenzodiazepinedrugsonhumanhealth
_version_	1718417155409575936

Risk assessment of the adverse impact of industrial synthesis of benzodiazepine drugs on human health

Ejemplares similares