Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy

Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically treated with PPV and followed up for 12 mont...

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Autores principales:	Faruk Nisic, Nina Jovanovic, Milka Mavija, Emina Alimanovic-Halilovic, Aida Nisic, Orhan Lepara, Adem Cemerlic
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	vascular endothelial growth factor biomarker postoperative complications proliferative diabetic retinopathy pars plana vitrectomy Medicine R
Acceso en línea:	https://doaj.org/article/b8035e84bbc34bfaa4f4df6eb10ccd12
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spelling	oai:doaj.org-article:b8035e84bbc34bfaa4f4df6eb10ccd122021-12-02T19:15:49ZVitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy1734-19221896-915110.5114/aoms.2018.73208https://doaj.org/article/b8035e84bbc34bfaa4f4df6eb10ccd122019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Vitreous-concentrations-of-vascular-endothelial-growth-factor-as-a-potential-biomarker,81618,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. A vitreous sample was obtained while performing the PPV procedure, using the Quantikine ELISA test to determine VEGF level, as a risk factor. Outcome measures were intraoperative and postoperative complications reported using categorical data: blunt and sharp dissection of membranes, intraoperative hemorrhage stopped by increasing infusion pressure, pressing with blunt instrument, or using diathermy. The following postoperative complications were assessed on the first day and at the 12-month follow-up visit: vitreous hemorrhage, fibrovascular proliferation (FVP), rubeosis iridis, and neovascular glaucoma (NVG). Results Levels of vitreous VEGF at the time of PPV were significantly higher in eyes with: vitreous hemorrhage on the first day after PPV (p = 0.003); FVP on the first day and 12 months after PPV (p = 0.002 and p < 0.001, respectively); iris rubeosis on the first day and 12 months after PPV surgery (p < 0.001, and p = 0.001, respectively); NVG on the first day and 12 months after PPV surgery (p = 0.043 and p = 0.011, respectively), compared to the eyes without complications. Conclusions Preoperative levels of VEGF in vitreous can be a useful biomarker and predictor of the postoperative outcome in terms of intraoperative and postoperative complications.Faruk NisicNina JovanovicMilka MavijaEmina Alimanovic-HalilovicAida NisicOrhan LeparaAdem CemerlicTermedia Publishing Housearticlevascular endothelial growth factorbiomarkerpostoperative complicationsproliferative diabetic retinopathypars plana vitrectomyMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 449-456 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular endothelial growth factor biomarker postoperative complications proliferative diabetic retinopathy pars plana vitrectomy Medicine R
spellingShingle	vascular endothelial growth factor biomarker postoperative complications proliferative diabetic retinopathy pars plana vitrectomy Medicine R Faruk Nisic Nina Jovanovic Milka Mavija Emina Alimanovic-Halilovic Aida Nisic Orhan Lepara Adem Cemerlic Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
description	Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. A vitreous sample was obtained while performing the PPV procedure, using the Quantikine ELISA test to determine VEGF level, as a risk factor. Outcome measures were intraoperative and postoperative complications reported using categorical data: blunt and sharp dissection of membranes, intraoperative hemorrhage stopped by increasing infusion pressure, pressing with blunt instrument, or using diathermy. The following postoperative complications were assessed on the first day and at the 12-month follow-up visit: vitreous hemorrhage, fibrovascular proliferation (FVP), rubeosis iridis, and neovascular glaucoma (NVG). Results Levels of vitreous VEGF at the time of PPV were significantly higher in eyes with: vitreous hemorrhage on the first day after PPV (p = 0.003); FVP on the first day and 12 months after PPV (p = 0.002 and p < 0.001, respectively); iris rubeosis on the first day and 12 months after PPV surgery (p < 0.001, and p = 0.001, respectively); NVG on the first day and 12 months after PPV surgery (p = 0.043 and p = 0.011, respectively), compared to the eyes without complications. Conclusions Preoperative levels of VEGF in vitreous can be a useful biomarker and predictor of the postoperative outcome in terms of intraoperative and postoperative complications.
format	article
author	Faruk Nisic Nina Jovanovic Milka Mavija Emina Alimanovic-Halilovic Aida Nisic Orhan Lepara Adem Cemerlic
author_facet	Faruk Nisic Nina Jovanovic Milka Mavija Emina Alimanovic-Halilovic Aida Nisic Orhan Lepara Adem Cemerlic
author_sort	Faruk Nisic
title	Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
title_short	Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
title_full	Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
title_fullStr	Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
title_full_unstemmed	Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
title_sort	vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/b8035e84bbc34bfaa4f4df6eb10ccd12
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Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy

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