Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers
Abstract This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in a stepwise manner, unless stopping criteria were met. P...
Saved in:
Main Authors: | Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Yuzo Horibuchi, Shuichi Iino, Shunji Matsuki, Yoichiro Ogama, Hiroyoshi Kakuyama |
---|---|
Format: | article |
Language: | EN |
Published: |
Wiley
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/b804592a5ce74d749d7cb7315b7cacf7 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Exposure-response analysis to assess concentration–QTc relationship of CC-122
by: Li Y, et al.
Published: (2016) -
QT/QTc safety and efficacy evaluation of teneligliptin in Indian type 2 diabetes mellitus patients: the “thorough QT/QTc” study (Q-SET study)
by: Erande S, et al.
Published: (2019) -
Prevalencia del Intervalo QT Prolongado en diferentes patrones electrocardiográficos: Estudio por Teleelectrocardiografía
by: Orellana A,Mirta, et al.
Published: (2009) - Amerasia journal
-
Evaluación y validación diagnóstica de las variables iQT, razón iQTRR, razón iRTRR para el diagnóstico DEQTc prolongado.
by: Santibáñez,Claudio, et al.
Published: (2020)