Large genome-wide association study identifies three novel risk variants for restless legs syndrome

Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subse...

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Autores principales:	Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja Van Den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a
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spelling	oai:doaj.org-article:b804eef352554c768c94ad94c5a8a74a2021-12-02T16:19:51ZLarge genome-wide association study identifies three novel risk variants for restless legs syndrome10.1038/s42003-020-01430-12399-3642https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01430-1https://doaj.org/toc/2399-3642Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.Maria DidriksenMuhammad Sulaman NawazJoseph DowsettSteven BellChristian ErikstrupOle B. PedersenErik SørensenPoul J. JennumKristoffer S. BurgdorfBrendan BurchellAdam S. ButterworthNicole SoranzoDavid B. RyeLynn Marie TrottiPrabhjyot SainiLilja StefansdottirSigurdur H. MagnussonGudmar ThorleifssonThordur SigmundssonAlbert P. SigurdssonKatja Van Den HurkFranke QueeMichael W. T. TanckWillem H. OuwehandDavid J. RobertsEric J. EarleyMichael P. BuschAlan E. MastGrier P. PageJohn DaneshEmanuele Di AngelantonioHreinn StefanssonHenrik UllumKari StefanssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maria Didriksen Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson Large genome-wide association study identifies three novel risk variants for restless legs syndrome
description	Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.
format	article
author	Maria Didriksen Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson
author_facet	Maria Didriksen Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson
author_sort	Maria Didriksen
title	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
title_short	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
title_full	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
title_fullStr	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
title_full_unstemmed	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
title_sort	large genome-wide association study identifies three novel risk variants for restless legs syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a
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Large genome-wide association study identifies three novel risk variants for restless legs syndrome

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