Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Diclofenac (DIC) is an NSAID that can cause toxic effects in animals and humans and carvacrol (CAR) is a monoterpene compound that displays effective pharmacological and biological actions. The purpose of this work was to assess the influences of CAR on DIC-induced renal injury and oxidative stress...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali Nouri, Farzad Izak-Shirian, Vahideh Fanaei, Maryam Dastan, Mahdieh Abolfathi, Alireza Moradi, Mansoor Khaledi, Hamzeh Mirshekari-Jahangiri
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Carvacrol Diclofenac Oxidative stress DIC-induced renal injury Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/b80a16b774f84adab6ab7caa39e9cd51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b80a16b774f84adab6ab7caa39e9cd51
record_format	dspace
spelling	oai:doaj.org-article:b80a16b774f84adab6ab7caa39e9cd512021-12-02T05:02:49ZCarvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response2405-844010.1016/j.heliyon.2021.e08358https://doaj.org/article/b80a16b774f84adab6ab7caa39e9cd512021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024610https://doaj.org/toc/2405-8440Diclofenac (DIC) is an NSAID that can cause toxic effects in animals and humans and carvacrol (CAR) is a monoterpene compound that displays effective pharmacological and biological actions. The purpose of this work was to assess the influences of CAR on DIC-induced renal injury and oxidative stress in male rats. The rats were segregated into four groups. Group 1, control group; Group 2 received DIC-only; Groups 3, received CAR-only and group 4 received DIC plus CAR. Changes in biochemical indexes, pathological changes, molecular biological indexes, and genes related to the inflammation of main organs were evaluated. The results of this work indicated that the amounts of the serum protein carbonyl, sGOT, sGPT, urea, creatinine, uric acid, nitrite content, MDA, serum TNF-α, and renal TNF-α gene expression were remarkably increased and the levels of the GPx, GSH, CAT, and SOD were significantly reduced in DIC-only treated animals compared to the control group. On the other hand, treatment with CAR after exposure to DIC led to significant improvements in abnormalities of DIC-induced renal injury and serum biochemical factors. The data approve that CAR diminished the deleterious effects of DIC exposure. In this regard, the findings of this study indicated that the administration of CAR could alleviate the noxious effects of DIC on the antioxidant defense system and renal tissue.Ali NouriFarzad Izak-ShirianVahideh FanaeiMaryam DastanMahdieh AbolfathiAlireza MoradiMansoor KhalediHamzeh Mirshekari-JahangiriElsevierarticleCarvacrolDiclofenacOxidative stressDIC-induced renal injuryScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08358- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carvacrol Diclofenac Oxidative stress DIC-induced renal injury Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Carvacrol Diclofenac Oxidative stress DIC-induced renal injury Science (General) Q1-390 Social sciences (General) H1-99 Ali Nouri Farzad Izak-Shirian Vahideh Fanaei Maryam Dastan Mahdieh Abolfathi Alireza Moradi Mansoor Khaledi Hamzeh Mirshekari-Jahangiri Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
description	Diclofenac (DIC) is an NSAID that can cause toxic effects in animals and humans and carvacrol (CAR) is a monoterpene compound that displays effective pharmacological and biological actions. The purpose of this work was to assess the influences of CAR on DIC-induced renal injury and oxidative stress in male rats. The rats were segregated into four groups. Group 1, control group; Group 2 received DIC-only; Groups 3, received CAR-only and group 4 received DIC plus CAR. Changes in biochemical indexes, pathological changes, molecular biological indexes, and genes related to the inflammation of main organs were evaluated. The results of this work indicated that the amounts of the serum protein carbonyl, sGOT, sGPT, urea, creatinine, uric acid, nitrite content, MDA, serum TNF-α, and renal TNF-α gene expression were remarkably increased and the levels of the GPx, GSH, CAT, and SOD were significantly reduced in DIC-only treated animals compared to the control group. On the other hand, treatment with CAR after exposure to DIC led to significant improvements in abnormalities of DIC-induced renal injury and serum biochemical factors. The data approve that CAR diminished the deleterious effects of DIC exposure. In this regard, the findings of this study indicated that the administration of CAR could alleviate the noxious effects of DIC on the antioxidant defense system and renal tissue.
format	article
author	Ali Nouri Farzad Izak-Shirian Vahideh Fanaei Maryam Dastan Mahdieh Abolfathi Alireza Moradi Mansoor Khaledi Hamzeh Mirshekari-Jahangiri
author_facet	Ali Nouri Farzad Izak-Shirian Vahideh Fanaei Maryam Dastan Mahdieh Abolfathi Alireza Moradi Mansoor Khaledi Hamzeh Mirshekari-Jahangiri
author_sort	Ali Nouri
title	Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
title_short	Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
title_full	Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
title_fullStr	Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
title_full_unstemmed	Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
title_sort	carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b80a16b774f84adab6ab7caa39e9cd51
work_keys_str_mv	AT alinouri carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT farzadizakshirian carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT vahidehfanaei carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT maryamdastan carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT mahdiehabolfathi carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT alirezamoradi carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT mansoorkhaledi carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse AT hamzehmirshekarijahangiri carvacrolexertsnephroprotectiveeffectinratmodelofdiclofenacinducedrenalinjurythroughregulationofoxidativestressandsuppressionofinflammatoryresponse
_version_	1718400733386113024

Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Ejemplares similares