Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.

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Autores principales: Gianluca Fulgenzi, Zhenyi Hong, Francesco Tomassoni-Ardori, Luiz F. Barella, Jodi Becker, Colleen Barrick, Deborah Swing, Sudhirkumar Yanpallewar, Brad St Croix, Jürgen Wess, Oksana Gavrilova, Lino Tessarollo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b80c90e12332437a928a3eef0743440d
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spelling oai:doaj.org-article:b80c90e12332437a928a3eef0743440d2021-12-02T17:32:59ZNovel metabolic role for BDNF in pancreatic β-cell insulin secretion10.1038/s41467-020-15833-52041-1723https://doaj.org/article/b80c90e12332437a928a3eef0743440d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15833-5https://doaj.org/toc/2041-1723Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.Gianluca FulgenziZhenyi HongFrancesco Tomassoni-ArdoriLuiz F. BarellaJodi BeckerColleen BarrickDeborah SwingSudhirkumar YanpallewarBrad St CroixJürgen WessOksana GavrilovaLino TessarolloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
description Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.
format article
author Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
author_facet Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
author_sort Gianluca Fulgenzi
title Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_short Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_full Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_fullStr Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_full_unstemmed Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_sort novel metabolic role for bdnf in pancreatic β-cell insulin secretion
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b80c90e12332437a928a3eef0743440d
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