Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.
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Nature Portfolio
2020
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oai:doaj.org-article:b80c90e12332437a928a3eef0743440d2021-12-02T17:32:59ZNovel metabolic role for BDNF in pancreatic β-cell insulin secretion10.1038/s41467-020-15833-52041-1723https://doaj.org/article/b80c90e12332437a928a3eef0743440d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15833-5https://doaj.org/toc/2041-1723Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.Gianluca FulgenziZhenyi HongFrancesco Tomassoni-ArdoriLuiz F. BarellaJodi BeckerColleen BarrickDeborah SwingSudhirkumar YanpallewarBrad St CroixJürgen WessOksana GavrilovaLino TessarolloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
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DOAJ |
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DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
description |
Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release. |
format |
article |
author |
Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo |
author_facet |
Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo |
author_sort |
Gianluca Fulgenzi |
title |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_short |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_full |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_fullStr |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_full_unstemmed |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_sort |
novel metabolic role for bdnf in pancreatic β-cell insulin secretion |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/b80c90e12332437a928a3eef0743440d |
work_keys_str_mv |
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