Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)

The objective of the current study was to evaluate the biochemical and immunological responses of tilapia, Oreochromis niloticus due to heavy metals pollution. Histomorphological alterations in the liver and kidney suggested tissue damages due to this polluted water exposure. The brain acetylcholine...

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Main Authors:	Zakir Hossain, Md. Saddam Hossain, Noore Safa Ema, Abdelwahab Omri
Format:	article
Language:	EN
Published:	Elsevier 2021
Subjects:	Acetylcholinesterase Antioxidant enzyme Cytokine Haematological indices Heavy metals Histopathological changes Science (General) Q1-390 Social sciences (General) H1-99
Online Access:	https://doaj.org/article/b80faff146e84f86a308b40df49e7bb5
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spelling	oai:doaj.org-article:b80faff146e84f86a308b40df49e7bb52021-12-02T05:02:26ZHeavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)2405-844010.1016/j.heliyon.2021.e08285https://doaj.org/article/b80faff146e84f86a308b40df49e7bb52021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023884https://doaj.org/toc/2405-8440The objective of the current study was to evaluate the biochemical and immunological responses of tilapia, Oreochromis niloticus due to heavy metals pollution. Histomorphological alterations in the liver and kidney suggested tissue damages due to this polluted water exposure. The brain acetylcholinesterase (AChE) as an indicator of neurotoxicity was significantly (P < 0.01) decreased after 10 days exposure of fish to heavy metal contained river water, while plasma glutamate oxalacetate transaminase and plasma glutamate pyruvate transaminase were significantly increased (P < 0.01). Moreover, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase enzyme activities, as well as reduced glutathione and malondialdehyde levels were significantly increased in heavy metals contained river water treated fish compared to the control. Additionally, glucose level and blood serum Ca2+ concentrations were significantly (P < 0.01) decreased in fish exposed to heavy metal contained river water compared to the control. Hematological indices such as Hemoglobin, RBC, WBC, MCV etc. of polluted river water treated fish were significantly (P < 0.01) different in comparison to that of control fish. The cytokines i.e. IL-1β, IL-6, and TNF-α level were significantly (P < 0.01) increased in the fish exposed to heavy metals contained river water in comparison to that of control fish. The present findings explored the detrimental effects of heavy metal contained river water on fish at biochemical and immunological levels.Zakir HossainMd. Saddam HossainNoore Safa EmaAbdelwahab OmriElsevierarticleAcetylcholinesteraseAntioxidant enzymeCytokineHaematological indicesHeavy metalsHistopathological changesScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08285- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acetylcholinesterase Antioxidant enzyme Cytokine Haematological indices Heavy metals Histopathological changes Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Acetylcholinesterase Antioxidant enzyme Cytokine Haematological indices Heavy metals Histopathological changes Science (General) Q1-390 Social sciences (General) H1-99 Zakir Hossain Md. Saddam Hossain Noore Safa Ema Abdelwahab Omri Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
description	The objective of the current study was to evaluate the biochemical and immunological responses of tilapia, Oreochromis niloticus due to heavy metals pollution. Histomorphological alterations in the liver and kidney suggested tissue damages due to this polluted water exposure. The brain acetylcholinesterase (AChE) as an indicator of neurotoxicity was significantly (P < 0.01) decreased after 10 days exposure of fish to heavy metal contained river water, while plasma glutamate oxalacetate transaminase and plasma glutamate pyruvate transaminase were significantly increased (P < 0.01). Moreover, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase enzyme activities, as well as reduced glutathione and malondialdehyde levels were significantly increased in heavy metals contained river water treated fish compared to the control. Additionally, glucose level and blood serum Ca2+ concentrations were significantly (P < 0.01) decreased in fish exposed to heavy metal contained river water compared to the control. Hematological indices such as Hemoglobin, RBC, WBC, MCV etc. of polluted river water treated fish were significantly (P < 0.01) different in comparison to that of control fish. The cytokines i.e. IL-1β, IL-6, and TNF-α level were significantly (P < 0.01) increased in the fish exposed to heavy metals contained river water in comparison to that of control fish. The present findings explored the detrimental effects of heavy metal contained river water on fish at biochemical and immunological levels.
format	article
author	Zakir Hossain Md. Saddam Hossain Noore Safa Ema Abdelwahab Omri
author_facet	Zakir Hossain Md. Saddam Hossain Noore Safa Ema Abdelwahab Omri
author_sort	Zakir Hossain
title	Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
title_short	Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
title_full	Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
title_fullStr	Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
title_full_unstemmed	Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)
title_sort	heavy metal toxicity in buriganga river alters the immunology of nile tilapia (oreochromis niloticus l)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b80faff146e84f86a308b40df49e7bb5
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Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)

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