Somatic growth, aging, and longevity
Abstract Although larger species of animals typically live longer than smaller species, the relationship of body size to longevity within a species is generally opposite. The longevity advantage of smaller individuals can be considerable and is best documented in laboratory mice and in domestic dogs...
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Nature Portfolio
2017
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oai:doaj.org-article:b8123ab9bf8b48a881d779620393f0182021-12-02T13:41:46ZSomatic growth, aging, and longevity10.1038/s41514-017-0014-y2056-3973https://doaj.org/article/b8123ab9bf8b48a881d779620393f0182017-09-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0014-yhttps://doaj.org/toc/2056-3973Abstract Although larger species of animals typically live longer than smaller species, the relationship of body size to longevity within a species is generally opposite. The longevity advantage of smaller individuals can be considerable and is best documented in laboratory mice and in domestic dogs. Importantly, it appears to apply broadly, including humans. It is not known whether theses associations represent causal links between various developmental and physiological mechanisms affecting growth and/or aging. However, variations in growth hormone (GH) signaling are likely involved because GH is a key stimulator of somatic growth, and apparently also exerts various “pro-aging” effects. Mechanisms linking GH, somatic growth, adult body size, aging, and lifespan likely involve target of rapamycin (TOR), particularly one of its signaling complexes, mTORC1, as well as various adjustments in mitochondrial function, energy metabolism, thermogenesis, inflammation, and insulin signaling. Somatic growth, aging, and longevity are also influenced by a variety of hormonal and nutritional signals, and much work will be needed to answer the question of why smaller individuals may be likely to live longer.Andrzej BartkeNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-6 (2017) |
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DOAJ |
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EN |
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Geriatrics RC952-954.6 |
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Geriatrics RC952-954.6 Andrzej Bartke Somatic growth, aging, and longevity |
| description |
Abstract Although larger species of animals typically live longer than smaller species, the relationship of body size to longevity within a species is generally opposite. The longevity advantage of smaller individuals can be considerable and is best documented in laboratory mice and in domestic dogs. Importantly, it appears to apply broadly, including humans. It is not known whether theses associations represent causal links between various developmental and physiological mechanisms affecting growth and/or aging. However, variations in growth hormone (GH) signaling are likely involved because GH is a key stimulator of somatic growth, and apparently also exerts various “pro-aging” effects. Mechanisms linking GH, somatic growth, adult body size, aging, and lifespan likely involve target of rapamycin (TOR), particularly one of its signaling complexes, mTORC1, as well as various adjustments in mitochondrial function, energy metabolism, thermogenesis, inflammation, and insulin signaling. Somatic growth, aging, and longevity are also influenced by a variety of hormonal and nutritional signals, and much work will be needed to answer the question of why smaller individuals may be likely to live longer. |
| format |
article |
| author |
Andrzej Bartke |
| author_facet |
Andrzej Bartke |
| author_sort |
Andrzej Bartke |
| title |
Somatic growth, aging, and longevity |
| title_short |
Somatic growth, aging, and longevity |
| title_full |
Somatic growth, aging, and longevity |
| title_fullStr |
Somatic growth, aging, and longevity |
| title_full_unstemmed |
Somatic growth, aging, and longevity |
| title_sort |
somatic growth, aging, and longevity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/b8123ab9bf8b48a881d779620393f018 |
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AT andrzejbartke somaticgrowthagingandlongevity |
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1718392577057619968 |