Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD<sup>+</sup> degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as...

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Auteurs principaux:	Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio De Flora, Elena Zocchi, Joerg Heeren, Santina Bruzzone
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	nicotinamide adenine dinucleotide CD38 adipose tissue Nutrition. Foods and food supply TX341-641
Accès en ligne:	https://doaj.org/article/b813c71d7dcf4d43b273465e65e0095b
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spelling	oai:doaj.org-article:b813c71d7dcf4d43b273465e65e0095b2021-11-25T18:33:36ZRole of CD38 in Adipose Tissue: Tuning Coenzyme Availability?10.3390/nu131137342072-6643https://doaj.org/article/b813c71d7dcf4d43b273465e65e0095b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3734https://doaj.org/toc/2072-6643Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD<sup>+</sup> degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca<sup>2+</sup>-mobilizing second messenger, starting from NAD<sup>+</sup>, and as the major NAD<sup>+</sup>-consumer, to be inhibited to increase NAD<sup>+</sup> levels. Indeed, the regulation of NAD<sup>+</sup> availability is a key event during different processes. In this review, we examine the recent studies related to the modulation of CD38 expression and activity, and the consequent changes in NAD(P)(H), in adipose tissue, during inflammation and cold-induced thermogenesis.Andrea BenziAlessia GrozioSonia SpinelliLaura SturlaAndreas H. GuseAntonio De FloraElena ZocchiJoerg HeerenSantina BruzzoneMDPI AGarticlenicotinamide adenine dinucleotideCD38adipose tissueNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3734, p 3734 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nicotinamide adenine dinucleotide CD38 adipose tissue Nutrition. Foods and food supply TX341-641
spellingShingle	nicotinamide adenine dinucleotide CD38 adipose tissue Nutrition. Foods and food supply TX341-641 Andrea Benzi Alessia Grozio Sonia Spinelli Laura Sturla Andreas H. Guse Antonio De Flora Elena Zocchi Joerg Heeren Santina Bruzzone Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
description	Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD<sup>+</sup> degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca<sup>2+</sup>-mobilizing second messenger, starting from NAD<sup>+</sup>, and as the major NAD<sup>+</sup>-consumer, to be inhibited to increase NAD<sup>+</sup> levels. Indeed, the regulation of NAD<sup>+</sup> availability is a key event during different processes. In this review, we examine the recent studies related to the modulation of CD38 expression and activity, and the consequent changes in NAD(P)(H), in adipose tissue, during inflammation and cold-induced thermogenesis.
format	article
author	Andrea Benzi Alessia Grozio Sonia Spinelli Laura Sturla Andreas H. Guse Antonio De Flora Elena Zocchi Joerg Heeren Santina Bruzzone
author_facet	Andrea Benzi Alessia Grozio Sonia Spinelli Laura Sturla Andreas H. Guse Antonio De Flora Elena Zocchi Joerg Heeren Santina Bruzzone
author_sort	Andrea Benzi
title	Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
title_short	Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
title_full	Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
title_fullStr	Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
title_full_unstemmed	Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
title_sort	role of cd38 in adipose tissue: tuning coenzyme availability?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b813c71d7dcf4d43b273465e65e0095b
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Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

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