Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.

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Autores principales:	Xue Gao, Shu-Hai Lin, Feng Ren, Jin-Tao Li, Jia-Jia Chen, Chuan-Bo Yao, Hong-Bin Yang, Shu-Xia Jiang, Guo-Quan Yan, Di Wang, Yi Wang, Ying Liu, Zongwei Cai, Ying-Ying Xu, Jing Chen, Wenqiang Yu, Peng-Yuan Yang, Qun-Ying Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8194c2aa98945ec80fb6bb93952191d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:b8194c2aa98945ec80fb6bb93952191d2021-12-02T16:57:03ZAcetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia10.1038/ncomms119602041-1723https://doaj.org/article/b8194c2aa98945ec80fb6bb93952191d2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11960https://doaj.org/toc/2041-1723Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.Xue GaoShu-Hai LinFeng RenJin-Tao LiJia-Jia ChenChuan-Bo YaoHong-Bin YangShu-Xia JiangGuo-Quan YanDi WangYi WangYing LiuZongwei CaiYing-Ying XuJing ChenWenqiang YuPeng-Yuan YangQun-Ying LeiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
description	Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.
format	article
author	Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei
author_facet	Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei
author_sort	Xue Gao
title	Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
title_short	Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
title_full	Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
title_fullStr	Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
title_full_unstemmed	Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
title_sort	acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b8194c2aa98945ec80fb6bb93952191d
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Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

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