Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?

Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PW...

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Autores principales:	Marta Bueno, Ester Boixadera-Planas, Laura Blanco-Hinojo, Susanna Esteba-Castillo, Olga Giménez-Palop, David Torrents-Rodas, Jesús Pujol, Raquel Corripio, Joan Deus, Assumpta Caixàs
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Prader-Willi syndrome obesity hunger satiety BDNF PYY Medicine R
Acceso en línea:	https://doaj.org/article/b81993b265084db89c4de07588ddbba1
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spelling	oai:doaj.org-article:b81993b265084db89c4de07588ddbba12021-11-11T17:47:02ZHunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?10.3390/jcm102151702077-0383https://doaj.org/article/b81993b265084db89c4de07588ddbba12021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5170https://doaj.org/toc/2077-0383Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27.5 ± 8.02 years; BMI 32.4 ± 8.14 kg/m<sup>2</sup>), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 0′, 30′, 60′ and 120′. Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.Marta BuenoEster Boixadera-PlanasLaura Blanco-HinojoSusanna Esteba-CastilloOlga Giménez-PalopDavid Torrents-RodasJesús PujolRaquel CorripioJoan DeusAssumpta CaixàsMDPI AGarticlePrader-Willi syndromeobesityhungersatietyBDNFPYYMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5170, p 5170 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prader-Willi syndrome obesity hunger satiety BDNF PYY Medicine R
spellingShingle	Prader-Willi syndrome obesity hunger satiety BDNF PYY Medicine R Marta Bueno Ester Boixadera-Planas Laura Blanco-Hinojo Susanna Esteba-Castillo Olga Giménez-Palop David Torrents-Rodas Jesús Pujol Raquel Corripio Joan Deus Assumpta Caixàs Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
description	Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27.5 ± 8.02 years; BMI 32.4 ± 8.14 kg/m<sup>2</sup>), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 0′, 30′, 60′ and 120′. Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.
format	article
author	Marta Bueno Ester Boixadera-Planas Laura Blanco-Hinojo Susanna Esteba-Castillo Olga Giménez-Palop David Torrents-Rodas Jesús Pujol Raquel Corripio Joan Deus Assumpta Caixàs
author_facet	Marta Bueno Ester Boixadera-Planas Laura Blanco-Hinojo Susanna Esteba-Castillo Olga Giménez-Palop David Torrents-Rodas Jesús Pujol Raquel Corripio Joan Deus Assumpta Caixàs
author_sort	Marta Bueno
title	Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_short	Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_full	Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_fullStr	Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_full_unstemmed	Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?
title_sort	hunger and satiety peptides: is there a pattern to classify patients with prader-willi syndrome?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b81993b265084db89c4de07588ddbba1
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Hunger and Satiety Peptides: Is There a Pattern to Classify Patients with Prader-Willi Syndrome?

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