C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

Delta-secretase cleaves both APP and Tau, and contributes to Alzheimer’s disease-like pathology. Here the authors show that C/EBPβ, a regulator of inflammation, also regulates transcription of delta-secretase in an age-dependent manner and contributes to Alzheimer’s disease-like pathology in mouse m...

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Autores principales:	Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b81c2e50214c4e409f44c39729818a47
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spelling	oai:doaj.org-article:b81c2e50214c4e409f44c39729818a472021-12-02T15:34:18ZC/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease10.1038/s41467-018-04120-z2041-1723https://doaj.org/article/b81c2e50214c4e409f44c39729818a472018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04120-zhttps://doaj.org/toc/2041-1723Delta-secretase cleaves both APP and Tau, and contributes to Alzheimer’s disease-like pathology. Here the authors show that C/EBPβ, a regulator of inflammation, also regulates transcription of delta-secretase in an age-dependent manner and contributes to Alzheimer’s disease-like pathology in mouse models.Zhi-Hao WangKe GongXia LiuZhentao ZhangXiaoou SunZheng Zachory WeiShan Ping YuFredric P. ManfredssonIvette M. SandovalPeter F. JohnsonJianping JiaJian-Zhi WangKeqiang YeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi-Hao Wang Ke Gong Xia Liu Zhentao Zhang Xiaoou Sun Zheng Zachory Wei Shan Ping Yu Fredric P. Manfredsson Ivette M. Sandoval Peter F. Johnson Jianping Jia Jian-Zhi Wang Keqiang Ye C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
description	Delta-secretase cleaves both APP and Tau, and contributes to Alzheimer’s disease-like pathology. Here the authors show that C/EBPβ, a regulator of inflammation, also regulates transcription of delta-secretase in an age-dependent manner and contributes to Alzheimer’s disease-like pathology in mouse models.
format	article
author	Zhi-Hao Wang Ke Gong Xia Liu Zhentao Zhang Xiaoou Sun Zheng Zachory Wei Shan Ping Yu Fredric P. Manfredsson Ivette M. Sandoval Peter F. Johnson Jianping Jia Jian-Zhi Wang Keqiang Ye
author_facet	Zhi-Hao Wang Ke Gong Xia Liu Zhentao Zhang Xiaoou Sun Zheng Zachory Wei Shan Ping Yu Fredric P. Manfredsson Ivette M. Sandoval Peter F. Johnson Jianping Jia Jian-Zhi Wang Keqiang Ye
author_sort	Zhi-Hao Wang
title	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
title_short	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
title_full	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
title_fullStr	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
title_full_unstemmed	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
title_sort	c/ebpβ regulates delta-secretase expression and mediates pathogenesis in mouse models of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b81c2e50214c4e409f44c39729818a47
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C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

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