Theoretical analysis on thermal treatment of skin with repetitive pulses

Abstract Thermal ablation is an efficient method of medical treatment, such as cancer therapy, wound closure, laser cutting, freckle removal and other treatments. In order to guarantee the curative effect and the safety of the patients, the thermal response of the tissue which is subjected to the he...

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Autores principales:	Jingxuan Ma, Xianfeng Yang, Yuxin Sun, Jialing Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b822b8630ca84c7f80bfc35433920657
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spelling	oai:doaj.org-article:b822b8630ca84c7f80bfc354339206572021-12-02T16:58:09ZTheoretical analysis on thermal treatment of skin with repetitive pulses10.1038/s41598-021-89395-x2045-2322https://doaj.org/article/b822b8630ca84c7f80bfc354339206572021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89395-xhttps://doaj.org/toc/2045-2322Abstract Thermal ablation is an efficient method of medical treatment, such as cancer therapy, wound closure, laser cutting, freckle removal and other treatments. In order to guarantee the curative effect and the safety of the patients, the thermal response of the tissue which is subjected to the heat source need to be carefully monitored. However, it is too difficult to achieve real-time monitoring on the full-field temperature. In the present study, efforts were made to build up a theoretical model for the prediction of the thermal response in the human skin. The Dual-Phase-Lag (DPL) bio-heat transfer model and the Henrique’s burn assessment model were employed to describe the interaction of multi-pulse heat source and the skin. The repeated multi-pulse laser is a common heat source in the thermal treatment and the thermal responses of the skin would be complicated under the common effects of the non-Fourier effects and the multi-pulse source. The Green’s function approach was used to solve the governing equations analytically. The closed-form solution for the temperature distribution of the skin was obtained and the thermal damage was estimated based on the temperature results. The influences of the biological parameters (the phase lags of the heat flux and the temperature gradient) and the heat source parameters (the pulse number and the duty ratio) on the temperature distribution, the burn degree and the irreversible burn depth of the irradiated region were discussed.Jingxuan MaXianfeng YangYuxin SunJialing YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingxuan Ma Xianfeng Yang Yuxin Sun Jialing Yang Theoretical analysis on thermal treatment of skin with repetitive pulses
description	Abstract Thermal ablation is an efficient method of medical treatment, such as cancer therapy, wound closure, laser cutting, freckle removal and other treatments. In order to guarantee the curative effect and the safety of the patients, the thermal response of the tissue which is subjected to the heat source need to be carefully monitored. However, it is too difficult to achieve real-time monitoring on the full-field temperature. In the present study, efforts were made to build up a theoretical model for the prediction of the thermal response in the human skin. The Dual-Phase-Lag (DPL) bio-heat transfer model and the Henrique’s burn assessment model were employed to describe the interaction of multi-pulse heat source and the skin. The repeated multi-pulse laser is a common heat source in the thermal treatment and the thermal responses of the skin would be complicated under the common effects of the non-Fourier effects and the multi-pulse source. The Green’s function approach was used to solve the governing equations analytically. The closed-form solution for the temperature distribution of the skin was obtained and the thermal damage was estimated based on the temperature results. The influences of the biological parameters (the phase lags of the heat flux and the temperature gradient) and the heat source parameters (the pulse number and the duty ratio) on the temperature distribution, the burn degree and the irreversible burn depth of the irradiated region were discussed.
format	article
author	Jingxuan Ma Xianfeng Yang Yuxin Sun Jialing Yang
author_facet	Jingxuan Ma Xianfeng Yang Yuxin Sun Jialing Yang
author_sort	Jingxuan Ma
title	Theoretical analysis on thermal treatment of skin with repetitive pulses
title_short	Theoretical analysis on thermal treatment of skin with repetitive pulses
title_full	Theoretical analysis on thermal treatment of skin with repetitive pulses
title_fullStr	Theoretical analysis on thermal treatment of skin with repetitive pulses
title_full_unstemmed	Theoretical analysis on thermal treatment of skin with repetitive pulses
title_sort	theoretical analysis on thermal treatment of skin with repetitive pulses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b822b8630ca84c7f80bfc35433920657
work_keys_str_mv	AT jingxuanma theoreticalanalysisonthermaltreatmentofskinwithrepetitivepulses AT xianfengyang theoreticalanalysisonthermaltreatmentofskinwithrepetitivepulses AT yuxinsun theoreticalanalysisonthermaltreatmentofskinwithrepetitivepulses AT jialingyang theoreticalanalysisonthermaltreatmentofskinwithrepetitivepulses
_version_	1718382411136368640

Theoretical analysis on thermal treatment of skin with repetitive pulses

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