Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation an...

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Autores principales:	Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8239efdcde244de83ae43188c91b2d3
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spelling	oai:doaj.org-article:b8239efdcde244de83ae43188c91b2d32021-12-02T16:58:15ZSelective small molecule PARG inhibitor causes replication fork stalling and cancer cell death10.1038/s41467-019-13508-42041-1723https://doaj.org/article/b8239efdcde244de83ae43188c91b2d32019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13508-4https://doaj.org/toc/2041-1723PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.Jerry H. HoulZu YeChris A. BroseyLakshitha P. F. Balapiti-ModarageSarita NamjoshiAlbino BacollaDaniel LavertyBrian L. WalkerYasin PourfarjamLeslie S. WardenNaga Babu ChinnamDavide MoianiRoderick A. StegemanMei-Kuang ChenMien-Chie HungZachary D. NagelTom EllenbergerIn-Kwon KimDarin E. JonesZamal AhmedJohn A. TainerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jerry H. Houl Zu Ye Chris A. Brosey Lakshitha P. F. Balapiti-Modarage Sarita Namjoshi Albino Bacolla Daniel Laverty Brian L. Walker Yasin Pourfarjam Leslie S. Warden Naga Babu Chinnam Davide Moiani Roderick A. Stegeman Mei-Kuang Chen Mien-Chie Hung Zachary D. Nagel Tom Ellenberger In-Kwon Kim Darin E. Jones Zamal Ahmed John A. Tainer Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
description	PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.
format	article
author	Jerry H. Houl Zu Ye Chris A. Brosey Lakshitha P. F. Balapiti-Modarage Sarita Namjoshi Albino Bacolla Daniel Laverty Brian L. Walker Yasin Pourfarjam Leslie S. Warden Naga Babu Chinnam Davide Moiani Roderick A. Stegeman Mei-Kuang Chen Mien-Chie Hung Zachary D. Nagel Tom Ellenberger In-Kwon Kim Darin E. Jones Zamal Ahmed John A. Tainer
author_facet	Jerry H. Houl Zu Ye Chris A. Brosey Lakshitha P. F. Balapiti-Modarage Sarita Namjoshi Albino Bacolla Daniel Laverty Brian L. Walker Yasin Pourfarjam Leslie S. Warden Naga Babu Chinnam Davide Moiani Roderick A. Stegeman Mei-Kuang Chen Mien-Chie Hung Zachary D. Nagel Tom Ellenberger In-Kwon Kim Darin E. Jones Zamal Ahmed John A. Tainer
author_sort	Jerry H. Houl
title	Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
title_short	Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
title_full	Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
title_fullStr	Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
title_full_unstemmed	Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
title_sort	selective small molecule parg inhibitor causes replication fork stalling and cancer cell death
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b8239efdcde244de83ae43188c91b2d3
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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

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