Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
The pharmacokinetic of enrofloxacin was investigated in brown trout (<i>Salmo trutta</i>) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against <i>Aeromonas hydrophila</i> and <i>A. sobria</i> were de...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b825243513a546b9a30d7f03bbbbba2b |
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| Sumario: | The pharmacokinetic of enrofloxacin was investigated in brown trout (<i>Salmo trutta</i>) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against <i>Aeromonas hydrophila</i> and <i>A. sobria</i> were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC<sub>0−</sub><sub>∞</sub>) and peak plasma concentrations (C<sub>max</sub>) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC<sub>0–</sub><sub>∞</sub> and C<sub>max</sub> were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for <i>A. hydrophila</i> and 0.0625–2 μg/mL for <i>A. sobria</i>. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for <i>A. hydrophila</i> and <i>A. sobria</i> with the MIC<sub>90</sub> values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by <i>A. hydrophila</i> and <i>A. sobria</i> in brown trout. |
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