Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against Aeromonas hydrophila and A. sobria were de...

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Autores principales:	Kamil Uney, Ertugrul Terzi, Duygu Durna Corum, Rahmi Can Ozdemir, Soner Bilen, Orhan Corum
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brown trout enrofloxacin pharmacokinetics pharmacodynamics Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/b825243513a546b9a30d7f03bbbbba2b
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spelling	oai:doaj.org-article:b825243513a546b9a30d7f03bbbbba2b2021-11-25T16:14:50ZPharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)10.3390/ani111130862076-2615https://doaj.org/article/b825243513a546b9a30d7f03bbbbba2b2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3086https://doaj.org/toc/2076-2615The pharmacokinetic of enrofloxacin was investigated in brown trout (<i>Salmo trutta</i>) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against <i>Aeromonas hydrophila</i> and <i>A. sobria</i> were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC<sub>0−</sub><sub>∞</sub>) and peak plasma concentrations (C<sub>max</sub>) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC<sub>0–</sub><sub>∞</sub> and C<sub>max</sub> were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for <i>A. hydrophila</i> and 0.0625–2 μg/mL for <i>A. sobria</i>. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for <i>A. hydrophila</i> and <i>A. sobria</i> with the MIC<sub>90</sub> values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by <i>A. hydrophila</i> and <i>A. sobria</i> in brown trout.Kamil UneyErtugrul TerziDuygu Durna CorumRahmi Can OzdemirSoner BilenOrhan CorumMDPI AGarticlebrown troutenrofloxacinpharmacokineticspharmacodynamicsVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3086, p 3086 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brown trout enrofloxacin pharmacokinetics pharmacodynamics Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	brown trout enrofloxacin pharmacokinetics pharmacodynamics Veterinary medicine SF600-1100 Zoology QL1-991 Kamil Uney Ertugrul Terzi Duygu Durna Corum Rahmi Can Ozdemir Soner Bilen Orhan Corum Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
description	The pharmacokinetic of enrofloxacin was investigated in brown trout (<i>Salmo trutta</i>) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against <i>Aeromonas hydrophila</i> and <i>A. sobria</i> were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC<sub>0−</sub><sub>∞</sub>) and peak plasma concentrations (C<sub>max</sub>) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC<sub>0–</sub><sub>∞</sub> and C<sub>max</sub> were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for <i>A. hydrophila</i> and 0.0625–2 μg/mL for <i>A. sobria</i>. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for <i>A. hydrophila</i> and <i>A. sobria</i> with the MIC<sub>90</sub> values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by <i>A. hydrophila</i> and <i>A. sobria</i> in brown trout.
format	article
author	Kamil Uney Ertugrul Terzi Duygu Durna Corum Rahmi Can Ozdemir Soner Bilen Orhan Corum
author_facet	Kamil Uney Ertugrul Terzi Duygu Durna Corum Rahmi Can Ozdemir Soner Bilen Orhan Corum
author_sort	Kamil Uney
title	Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
title_short	Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
title_full	Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
title_fullStr	Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
title_full_unstemmed	Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
title_sort	pharmacokinetics and pharmacokinetic/pharmacodynamic integration of enrofloxacin following single oral administration of different doses in brown trout (<i>salmo trutta</i>)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b825243513a546b9a30d7f03bbbbba2b
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Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)

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