The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.

The integrity of structural connectivity in a functional brain network supports the efficiency of neural processing within relevant brain regions. This study aimed to quantitatively investigate the short- and long-range fibers, and their differential roles in the lower cognitive efficiency in aging...

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Autores principales:	Junling Gao, Raymond T F Cheung, Ying-Shing Chan, Leung-Wing Chu, Henry K F Mak, Tatia M C Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b82787f9b0a2440da3051572a65fb2f4
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spelling	oai:doaj.org-article:b82787f9b0a2440da3051572a65fb2f42021-11-18T08:25:22ZThe relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.1932-620310.1371/journal.pone.0090307https://doaj.org/article/b82787f9b0a2440da3051572a65fb2f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24694731/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The integrity of structural connectivity in a functional brain network supports the efficiency of neural processing within relevant brain regions. This study aimed to quantitatively investigate the short- and long-range fibers, and their differential roles in the lower cognitive efficiency in aging and dementia. Three groups of healthy young, healthy older adults and patients with Alzheimer's disease (AD) participated in this combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) study on prospective memory (PM). Short- and long-range fiber tracts within the PM task engaged brain networks were generated. The correlation between the fMRI signal change, PM performance and the DTI characters were calculated. FMRI results showed that the PM-specific frontal activations in three groups were distributed hierarchically along the rostrocaudal axis in the frontal lobe. In an overall PM condition generally activated brain network among the three groups, tractography was used to generate the short-range fibers, and they were found impaired in both healthy older adults and AD patients. However, the long-range fiber tracts were only impaired in AD. Additionally, the mean diffusivity (MD) of short-range but not long-range fibers was positively correlated with fMRI signal change and negatively correlated with the efficiency of PM performance. This study suggests that the disintegrity of short-range fibers may contribute more to the lower cognitive efficiency and higher compensatory brain activation in healthy older adults and more in AD patients.Junling GaoRaymond T F CheungYing-Shing ChanLeung-Wing ChuHenry K F MakTatia M C LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e90307 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junling Gao Raymond T F Cheung Ying-Shing Chan Leung-Wing Chu Henry K F Mak Tatia M C Lee The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
description	The integrity of structural connectivity in a functional brain network supports the efficiency of neural processing within relevant brain regions. This study aimed to quantitatively investigate the short- and long-range fibers, and their differential roles in the lower cognitive efficiency in aging and dementia. Three groups of healthy young, healthy older adults and patients with Alzheimer's disease (AD) participated in this combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) study on prospective memory (PM). Short- and long-range fiber tracts within the PM task engaged brain networks were generated. The correlation between the fMRI signal change, PM performance and the DTI characters were calculated. FMRI results showed that the PM-specific frontal activations in three groups were distributed hierarchically along the rostrocaudal axis in the frontal lobe. In an overall PM condition generally activated brain network among the three groups, tractography was used to generate the short-range fibers, and they were found impaired in both healthy older adults and AD patients. However, the long-range fiber tracts were only impaired in AD. Additionally, the mean diffusivity (MD) of short-range but not long-range fibers was positively correlated with fMRI signal change and negatively correlated with the efficiency of PM performance. This study suggests that the disintegrity of short-range fibers may contribute more to the lower cognitive efficiency and higher compensatory brain activation in healthy older adults and more in AD patients.
format	article
author	Junling Gao Raymond T F Cheung Ying-Shing Chan Leung-Wing Chu Henry K F Mak Tatia M C Lee
author_facet	Junling Gao Raymond T F Cheung Ying-Shing Chan Leung-Wing Chu Henry K F Mak Tatia M C Lee
author_sort	Junling Gao
title	The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
title_short	The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
title_full	The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
title_fullStr	The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
title_full_unstemmed	The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
title_sort	relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b82787f9b0a2440da3051572a65fb2f4
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The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.

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