Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.

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Autores principales:	Haocheng Zhou, Qiaosheng Zhang, Erik Martinez, Jahrane Dale, Sile Hu, Eric Zhang, Kevin Liu, Dong Huang, Guang Yang, Zhe Chen, Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b82852a840c54a4e991a75bd2637c954
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spelling	oai:doaj.org-article:b82852a840c54a4e991a75bd2637c9542021-12-02T16:49:22ZKetamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex10.1038/s41467-018-06295-x2041-1723https://doaj.org/article/b82852a840c54a4e991a75bd2637c9542018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06295-xhttps://doaj.org/toc/2041-1723Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.Haocheng ZhouQiaosheng ZhangErik MartinezJahrane DaleSile HuEric ZhangKevin LiuDong HuangGuang YangZhe ChenJing WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haocheng Zhou Qiaosheng Zhang Erik Martinez Jahrane Dale Sile Hu Eric Zhang Kevin Liu Dong Huang Guang Yang Zhe Chen Jing Wang Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
description	Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.
format	article
author	Haocheng Zhou Qiaosheng Zhang Erik Martinez Jahrane Dale Sile Hu Eric Zhang Kevin Liu Dong Huang Guang Yang Zhe Chen Jing Wang
author_facet	Haocheng Zhou Qiaosheng Zhang Erik Martinez Jahrane Dale Sile Hu Eric Zhang Kevin Liu Dong Huang Guang Yang Zhe Chen Jing Wang
author_sort	Haocheng Zhou
title	Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
title_short	Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
title_full	Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
title_fullStr	Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
title_full_unstemmed	Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
title_sort	ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b82852a840c54a4e991a75bd2637c954
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Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

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