Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.

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Bibliographic Details
Main Authors: Haocheng Zhou, Qiaosheng Zhang, Erik Martinez, Jahrane Dale, Sile Hu, Eric Zhang, Kevin Liu, Dong Huang, Guang Yang, Zhe Chen, Jing Wang
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/b82852a840c54a4e991a75bd2637c954
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