Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding.
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Nature Portfolio
2016
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oai:doaj.org-article:b82a72dd5f0a44099bcaaa35fbf303492021-12-02T14:38:34ZAlternative splicing of MALT1 controls signalling and activation of CD4+ T cells10.1038/ncomms112922041-1723https://doaj.org/article/b82a72dd5f0a44099bcaaa35fbf303492016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11292https://doaj.org/toc/2041-1723MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding.Isabel MeiningerRichard A. GriesbachDesheng HuTorben GehringThomas SeeholzerArianna BertossiJan KranichAndrea OeckinghausAndrea C. EitelhuberUte GreczmielAndreas GewiesMarc Schmidt-SupprianJürgen RulandThomas BrockerVigo HeissmeyerFlorian HeydDaniel KrappmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Isabel Meininger Richard A. Griesbach Desheng Hu Torben Gehring Thomas Seeholzer Arianna Bertossi Jan Kranich Andrea Oeckinghaus Andrea C. Eitelhuber Ute Greczmiel Andreas Gewies Marc Schmidt-Supprian Jürgen Ruland Thomas Brocker Vigo Heissmeyer Florian Heyd Daniel Krappmann Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| description |
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding. |
| format |
article |
| author |
Isabel Meininger Richard A. Griesbach Desheng Hu Torben Gehring Thomas Seeholzer Arianna Bertossi Jan Kranich Andrea Oeckinghaus Andrea C. Eitelhuber Ute Greczmiel Andreas Gewies Marc Schmidt-Supprian Jürgen Ruland Thomas Brocker Vigo Heissmeyer Florian Heyd Daniel Krappmann |
| author_facet |
Isabel Meininger Richard A. Griesbach Desheng Hu Torben Gehring Thomas Seeholzer Arianna Bertossi Jan Kranich Andrea Oeckinghaus Andrea C. Eitelhuber Ute Greczmiel Andreas Gewies Marc Schmidt-Supprian Jürgen Ruland Thomas Brocker Vigo Heissmeyer Florian Heyd Daniel Krappmann |
| author_sort |
Isabel Meininger |
| title |
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| title_short |
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| title_full |
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| title_fullStr |
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| title_full_unstemmed |
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells |
| title_sort |
alternative splicing of malt1 controls signalling and activation of cd4+ t cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b82a72dd5f0a44099bcaaa35fbf30349 |
| work_keys_str_mv |
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| _version_ |
1718390974407770112 |