Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial
OBJECTIVES:. This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest. DESIGN:. A randomized two-group single-blinded phase 2 clinical drug trial. SETTING:. A multipurpose ICU i...
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Wolters Kluwer
2021
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oai:doaj.org-article:b8323a7599b845a3bff9321226cde5032021-11-25T07:55:46ZEffect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial2639-802810.1097/CCE.0000000000000502https://doaj.org/article/b8323a7599b845a3bff9321226cde5032021-08-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000502https://doaj.org/toc/2639-8028OBJECTIVES:. This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest. DESIGN:. A randomized two-group single-blinded phase 2 clinical drug trial. SETTING:. A multipurpose ICU in two university hospitals. PATIENTS:. Of the 110 randomized comatose survivors after out-of-hospital cardiac arrest with a shockable rhythm in the xenon in combination with hypothermia after cardiac arrest trial, 38 patients (24–76 yr old) with complete echocardiography were included in this study. INTERVENTIONS:. Patients were randomized to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours or hypothermia treatment alone. Echocardiography was performed at hospital admission and 24 ± 4 hours after hypothermia. MEASUREMENTS AND MAIN RESULTS:. Left ventricular ejection fraction, myocardial longitudinal systolic strain, and diastolic function were analyzed blinded to treatment. There were 17 xenon and 21 control patients in whom echocardiography was completed. Clinical characteristics did not differ significantly between the groups. At admission, ejection fraction was similar in xenon and control patients (39% ± 10% vs 38% ± 11%; p = 0.711) but higher in xenon than control patients after hypothermia (50% ± 10% vs 42% ± 10%; p = 0.014). Global longitudinal systolic strain was similar in xenon and control patients at admission (–9.0% ± 3.8% vs –8.1% ± 3.6%; p = 0.555) but better in xenon than control patients after hypothermia (–14.4.0% ± 4.0% vs –10.5% ± 4.0%; p = 0.006). In patients with coronary artery disease, longitudinal strain improved in the nonischemic myocardial segments in xenon patients. There were no changes in diastolic function between the groups. CONCLUSIONS:. Among comatose survivors of a cardiac cause out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia was associated with greater recovery of left ventricular systolic function in comparison with hypothermia alone.Antti Saraste, MD, PhDHaitham Ballo, MDOlli Arola, MD, PhDRuut Laitio, MD, PhDJuhani Airaksinen, MD, PhDMarja Hynninen, MD, PhDMinna Bäcklund, MD, PhDEmmi Ylikoski, MD, PhDJohanna Wennervirta, MD, PhDMikko Pietilä, MD, PhDRisto O. Roine, MD, PhDVeli-Pekka Harjola, MD, PhDJussi Niiranen, MD, PhDKirsi Korpi, MD, PhDMarjut Varpula, MD, PhDHarry Scheinin, MD, PhDMervyn Maze, MB ChBTero Vahlberg, MScTimo Laitio, MD, PhDfor the Xe-HYPOTHECA Study GroupSami VirtanenRiitta ParkkolaJani SaunavaaraJuha MartolaHeli SilvennoinenMarjaana TiainenJuha GrönlundOuti InkinenPäivi SilvastiEija NukarinenKlaus T. OlkkolaWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 3, Iss 8, p e0502 (2021) |
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| collection |
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| topic |
Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 |
| spellingShingle |
Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Antti Saraste, MD, PhD Haitham Ballo, MD Olli Arola, MD, PhD Ruut Laitio, MD, PhD Juhani Airaksinen, MD, PhD Marja Hynninen, MD, PhD Minna Bäcklund, MD, PhD Emmi Ylikoski, MD, PhD Johanna Wennervirta, MD, PhD Mikko Pietilä, MD, PhD Risto O. Roine, MD, PhD Veli-Pekka Harjola, MD, PhD Jussi Niiranen, MD, PhD Kirsi Korpi, MD, PhD Marjut Varpula, MD, PhD Harry Scheinin, MD, PhD Mervyn Maze, MB ChB Tero Vahlberg, MSc Timo Laitio, MD, PhD for the Xe-HYPOTHECA Study Group Sami Virtanen Riitta Parkkola Jani Saunavaara Juha Martola Heli Silvennoinen Marjaana Tiainen Juha Grönlund Outi Inkinen Päivi Silvasti Eija Nukarinen Klaus T. Olkkola Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| description |
OBJECTIVES:. This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest.
DESIGN:. A randomized two-group single-blinded phase 2 clinical drug trial.
SETTING:. A multipurpose ICU in two university hospitals.
PATIENTS:. Of the 110 randomized comatose survivors after out-of-hospital cardiac arrest with a shockable rhythm in the xenon in combination with hypothermia after cardiac arrest trial, 38 patients (24–76 yr old) with complete echocardiography were included in this study.
INTERVENTIONS:. Patients were randomized to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours or hypothermia treatment alone. Echocardiography was performed at hospital admission and 24 ± 4 hours after hypothermia.
MEASUREMENTS AND MAIN RESULTS:. Left ventricular ejection fraction, myocardial longitudinal systolic strain, and diastolic function were analyzed blinded to treatment. There were 17 xenon and 21 control patients in whom echocardiography was completed. Clinical characteristics did not differ significantly between the groups. At admission, ejection fraction was similar in xenon and control patients (39% ± 10% vs 38% ± 11%; p = 0.711) but higher in xenon than control patients after hypothermia (50% ± 10% vs 42% ± 10%; p = 0.014). Global longitudinal systolic strain was similar in xenon and control patients at admission (–9.0% ± 3.8% vs –8.1% ± 3.6%; p = 0.555) but better in xenon than control patients after hypothermia (–14.4.0% ± 4.0% vs –10.5% ± 4.0%; p = 0.006). In patients with coronary artery disease, longitudinal strain improved in the nonischemic myocardial segments in xenon patients. There were no changes in diastolic function between the groups.
CONCLUSIONS:. Among comatose survivors of a cardiac cause out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia was associated with greater recovery of left ventricular systolic function in comparison with hypothermia alone. |
| format |
article |
| author |
Antti Saraste, MD, PhD Haitham Ballo, MD Olli Arola, MD, PhD Ruut Laitio, MD, PhD Juhani Airaksinen, MD, PhD Marja Hynninen, MD, PhD Minna Bäcklund, MD, PhD Emmi Ylikoski, MD, PhD Johanna Wennervirta, MD, PhD Mikko Pietilä, MD, PhD Risto O. Roine, MD, PhD Veli-Pekka Harjola, MD, PhD Jussi Niiranen, MD, PhD Kirsi Korpi, MD, PhD Marjut Varpula, MD, PhD Harry Scheinin, MD, PhD Mervyn Maze, MB ChB Tero Vahlberg, MSc Timo Laitio, MD, PhD for the Xe-HYPOTHECA Study Group Sami Virtanen Riitta Parkkola Jani Saunavaara Juha Martola Heli Silvennoinen Marjaana Tiainen Juha Grönlund Outi Inkinen Päivi Silvasti Eija Nukarinen Klaus T. Olkkola |
| author_facet |
Antti Saraste, MD, PhD Haitham Ballo, MD Olli Arola, MD, PhD Ruut Laitio, MD, PhD Juhani Airaksinen, MD, PhD Marja Hynninen, MD, PhD Minna Bäcklund, MD, PhD Emmi Ylikoski, MD, PhD Johanna Wennervirta, MD, PhD Mikko Pietilä, MD, PhD Risto O. Roine, MD, PhD Veli-Pekka Harjola, MD, PhD Jussi Niiranen, MD, PhD Kirsi Korpi, MD, PhD Marjut Varpula, MD, PhD Harry Scheinin, MD, PhD Mervyn Maze, MB ChB Tero Vahlberg, MSc Timo Laitio, MD, PhD for the Xe-HYPOTHECA Study Group Sami Virtanen Riitta Parkkola Jani Saunavaara Juha Martola Heli Silvennoinen Marjaana Tiainen Juha Grönlund Outi Inkinen Päivi Silvasti Eija Nukarinen Klaus T. Olkkola |
| author_sort |
Antti Saraste, MD, PhD |
| title |
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| title_short |
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| title_full |
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| title_fullStr |
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| title_full_unstemmed |
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial |
| title_sort |
effect of inhaled xenon on cardiac function in comatose survivors of out-of-hospital cardiac arrest—a substudy of the xenon in combination with hypothermia after cardiac arrest trial |
| publisher |
Wolters Kluwer |
| publishDate |
2021 |
| url |
https://doaj.org/article/b8323a7599b845a3bff9321226cde503 |
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