Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications

Ross A McDevitt,1 Sean J Reed,2 Jonathan P Britt2,3 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; 2Integrated Program in Neuroscience, Montreal Neurological Institute, 3Department of Psychology, McGill University, Montreal, QC, C...

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Autores principales:	McDevitt RA, Reed SJ, Britt JP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b833782657eb403e816d3049381d267a
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spelling	oai:doaj.org-article:b833782657eb403e816d3049381d267a2021-12-02T07:16:52ZOptogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications1178-2021https://doaj.org/article/b833782657eb403e816d3049381d267a2014-07-01T00:00:00Zhttp://www.dovepress.com/optogenetics-in-preclinical-neuroscience-and-psychiatry-research-recen-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ross A McDevitt,1 Sean J Reed,2 Jonathan P Britt2,3 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; 2Integrated Program in Neuroscience, Montreal Neurological Institute, 3Department of Psychology, McGill University, Montreal, QC, Canada Abstract: There have been significant advances in the treatment of psychiatric disease in the last half century, but it is still unclear which neural circuits are ultimately responsible for specific disease states. Fortunately, technical limitations that have constrained this research have recently been mitigated by advances in research tools that facilitate circuit-based analyses. The most prominent of these tools is optogenetics, which refers to the use of genetically encoded, light-sensitive proteins that can be used to manipulate discrete neural circuits with temporal precision. Optogenetics has recently been used to examine the neural underpinnings of both psychiatric disease and symptom relief, and this research has rapidly identified novel therapeutic targets for what could be a new generation of rational drug development. As these and related methodologies for controlling neurons ultimately make their way into the clinic, circuit-based strategies for alleviating psychiatric symptoms could become a remarkably refined approach to disease treatment. Keywords: optogenetics, depression, anxiety, addiction, obsessive-compulsive disorderMcDevitt RAReed SJBritt JPDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1369-1379 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 McDevitt RA Reed SJ Britt JP Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
description	Ross A McDevitt,1 Sean J Reed,2 Jonathan P Britt2,3 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; 2Integrated Program in Neuroscience, Montreal Neurological Institute, 3Department of Psychology, McGill University, Montreal, QC, Canada Abstract: There have been significant advances in the treatment of psychiatric disease in the last half century, but it is still unclear which neural circuits are ultimately responsible for specific disease states. Fortunately, technical limitations that have constrained this research have recently been mitigated by advances in research tools that facilitate circuit-based analyses. The most prominent of these tools is optogenetics, which refers to the use of genetically encoded, light-sensitive proteins that can be used to manipulate discrete neural circuits with temporal precision. Optogenetics has recently been used to examine the neural underpinnings of both psychiatric disease and symptom relief, and this research has rapidly identified novel therapeutic targets for what could be a new generation of rational drug development. As these and related methodologies for controlling neurons ultimately make their way into the clinic, circuit-based strategies for alleviating psychiatric symptoms could become a remarkably refined approach to disease treatment. Keywords: optogenetics, depression, anxiety, addiction, obsessive-compulsive disorder
format	article
author	McDevitt RA Reed SJ Britt JP
author_facet	McDevitt RA Reed SJ Britt JP
author_sort	McDevitt RA
title	Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
title_short	Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
title_full	Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
title_fullStr	Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
title_full_unstemmed	Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
title_sort	optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b833782657eb403e816d3049381d267a
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Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications

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