Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-kn...

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Autor principal:	Yan LJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	5-methoxyindole-2-carboxylic acid anti-diabetic diabetes dihydrolipoamide dehydrogenase gluconeogenesis mitochondria Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b833a3af5e924b689350ea6d68a25d01
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spelling	oai:doaj.org-article:b833a3af5e924b689350ea6d68a25d012021-12-02T07:22:43ZReexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent1178-7007https://doaj.org/article/b833a3af5e924b689350ea6d68a25d012018-05-01T00:00:00Zhttps://www.dovepress.com/reexploring-5-methoxyindole-2-carboxylic-acid-mica-as-a-potential-anti-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent. Keywords: 5-methoxyindole-2-carboxylic acid, antidiabetic, diabetes, dihydrolipoamide dehydrogenase, gluconeogenesis, mitochondriaYan LJDove Medical Pressarticle5-methoxyindole-2-carboxylic acidanti-diabeticdiabetesdihydrolipoamide dehydrogenasegluconeogenesismitochondriaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 183-186 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	5-methoxyindole-2-carboxylic acid anti-diabetic diabetes dihydrolipoamide dehydrogenase gluconeogenesis mitochondria Specialties of internal medicine RC581-951
spellingShingle	5-methoxyindole-2-carboxylic acid anti-diabetic diabetes dihydrolipoamide dehydrogenase gluconeogenesis mitochondria Specialties of internal medicine RC581-951 Yan LJ Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
description	Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent. Keywords: 5-methoxyindole-2-carboxylic acid, antidiabetic, diabetes, dihydrolipoamide dehydrogenase, gluconeogenesis, mitochondria
format	article
author	Yan LJ
author_facet	Yan LJ
author_sort	Yan LJ
title	Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_short	Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_full	Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_fullStr	Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_full_unstemmed	Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_sort	reexploring 5-methoxyindole-2-carboxylic acid (mica) as a potential antidiabetic agent
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b833a3af5e924b689350ea6d68a25d01
work_keys_str_mv	AT yanlj reexploring5methoxyindole2carboxylicacidmicaasapotentialantidiabeticagent
_version_	1718399475104350208

Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

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