Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.

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Autores principales:	A. Kliewer, F. Schmiedel, S. Sianati, A. Bailey, J. T. Bateman, E. S. Levitt, J. T. Williams, M. J. Christie, S. Schulz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b83824d898a24fdaa874d8ad8f4ffcb3
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spelling	oai:doaj.org-article:b83824d898a24fdaa874d8ad8f4ffcb32021-12-02T14:35:30ZPhosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects10.1038/s41467-018-08162-12041-1723https://doaj.org/article/b83824d898a24fdaa874d8ad8f4ffcb32019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08162-1https://doaj.org/toc/2041-1723Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.A. KliewerF. SchmiedelS. SianatiA. BaileyJ. T. BatemanE. S. LevittJ. T. WilliamsM. J. ChristieS. SchulzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Kliewer F. Schmiedel S. Sianati A. Bailey J. T. Bateman E. S. Levitt J. T. Williams M. J. Christie S. Schulz Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
description	Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.
format	article
author	A. Kliewer F. Schmiedel S. Sianati A. Bailey J. T. Bateman E. S. Levitt J. T. Williams M. J. Christie S. Schulz
author_facet	A. Kliewer F. Schmiedel S. Sianati A. Bailey J. T. Bateman E. S. Levitt J. T. Williams M. J. Christie S. Schulz
author_sort	A. Kliewer
title	Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
title_short	Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
title_full	Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
title_fullStr	Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
title_full_unstemmed	Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
title_sort	phosphorylation-deficient g-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b83824d898a24fdaa874d8ad8f4ffcb3
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Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

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