Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19
Abstract To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 an...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b840857c5b314b6aa3bca0d31e38bac7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b840857c5b314b6aa3bca0d31e38bac7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b840857c5b314b6aa3bca0d31e38bac72021-12-02T16:08:37ZFactors associated with acute cardiac injury and their effects on mortality in patients with COVID-1910.1038/s41598-020-77172-12045-2322https://doaj.org/article/b840857c5b314b6aa3bca0d31e38bac72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77172-1https://doaj.org/toc/2045-2322Abstract To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 and March 29, 2020 were included. The demographic, clinical characteristics, laboratory, radiological and treatment data were collected. Univariate and Firth logistic regression analyses were used to identify factors associated with ACI and in-hospital mortality, and Kaplan–Meier method was used to estimate cumulative in-hospital mortality. Among 1031 patients included, 215 (20.7%) had ACI and 501 (48.6%) were severe cases. Overall, 165 patients died; all were from the severe group, and 131 (79.39%) had ACI. ACI (OR = 2.34, P = 0.009), male gender (OR = 2.58, P = 0.001), oximeter oxygen saturation (OR = 0.90, P < 0.001), lactate dehydrogenase (OR = 3.26, P < 0.001), interleukin-6 (IL-6) (OR = 8.59, P < 0.001), high sensitivity C-reactive protein (hs-CRP) (OR = 3.29, P = 0.016), N-terminal pro brain natriuretic peptide (NT-proBNP) (OR = 2.94, P = 0.001) were independent risk factors for the in-hospital mortality in severe patients. The mortality was significantly increased among severe patients with elevated hs-CRP, IL-6, hs-cTnI, and/or NT-proBNP. Moreover, the mortality was significantly higher in patients with elevation of both hs-cTnI and NT proBNP than in those with elevation of either of them. ACI develops in a substantial proportion of patients with COVID-19, and is associated with the disease severity and in-hospital mortality. A combination of hs-cTnI and NT-proBNP is valuable in predicting the mortality.Xingwei HeLuyan WangHongjie WangYang XieYongfu YuJianhua SunJiangbo YanYuxin DuYin ShenHesong ZengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Xingwei He Luyan Wang Hongjie Wang Yang Xie Yongfu Yu Jianhua Sun Jiangbo Yan Yuxin Du Yin Shen Hesong Zeng Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| description |
Abstract To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 and March 29, 2020 were included. The demographic, clinical characteristics, laboratory, radiological and treatment data were collected. Univariate and Firth logistic regression analyses were used to identify factors associated with ACI and in-hospital mortality, and Kaplan–Meier method was used to estimate cumulative in-hospital mortality. Among 1031 patients included, 215 (20.7%) had ACI and 501 (48.6%) were severe cases. Overall, 165 patients died; all were from the severe group, and 131 (79.39%) had ACI. ACI (OR = 2.34, P = 0.009), male gender (OR = 2.58, P = 0.001), oximeter oxygen saturation (OR = 0.90, P < 0.001), lactate dehydrogenase (OR = 3.26, P < 0.001), interleukin-6 (IL-6) (OR = 8.59, P < 0.001), high sensitivity C-reactive protein (hs-CRP) (OR = 3.29, P = 0.016), N-terminal pro brain natriuretic peptide (NT-proBNP) (OR = 2.94, P = 0.001) were independent risk factors for the in-hospital mortality in severe patients. The mortality was significantly increased among severe patients with elevated hs-CRP, IL-6, hs-cTnI, and/or NT-proBNP. Moreover, the mortality was significantly higher in patients with elevation of both hs-cTnI and NT proBNP than in those with elevation of either of them. ACI develops in a substantial proportion of patients with COVID-19, and is associated with the disease severity and in-hospital mortality. A combination of hs-cTnI and NT-proBNP is valuable in predicting the mortality. |
| format |
article |
| author |
Xingwei He Luyan Wang Hongjie Wang Yang Xie Yongfu Yu Jianhua Sun Jiangbo Yan Yuxin Du Yin Shen Hesong Zeng |
| author_facet |
Xingwei He Luyan Wang Hongjie Wang Yang Xie Yongfu Yu Jianhua Sun Jiangbo Yan Yuxin Du Yin Shen Hesong Zeng |
| author_sort |
Xingwei He |
| title |
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| title_short |
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| title_full |
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| title_fullStr |
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| title_full_unstemmed |
Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19 |
| title_sort |
factors associated with acute cardiac injury and their effects on mortality in patients with covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b840857c5b314b6aa3bca0d31e38bac7 |
| work_keys_str_mv |
AT xingweihe factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT luyanwang factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT hongjiewang factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT yangxie factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT yongfuyu factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT jianhuasun factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT jiangboyan factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT yuxindu factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT yinshen factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 AT hesongzeng factorsassociatedwithacutecardiacinjuryandtheireffectsonmortalityinpatientswithcovid19 |
| _version_ |
1718384491283611648 |