High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants...

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Autores principales:	Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1
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spelling	oai:doaj.org-article:b840b6fe3d734ff1922a52f00577dac12021-12-02T17:32:02ZHigh-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human10.1038/s41467-018-07746-12041-1723https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac12018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07746-1https://doaj.org/toc/2041-1723Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants.Xinchen WangLiang HeSarah M. GogginAlham SaadatLi WangNasa Sinnott-ArmstrongMelina ClaussnitzerManolis KellisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinchen Wang Liang He Sarah M. Goggin Alham Saadat Li Wang Nasa Sinnott-Armstrong Melina Claussnitzer Manolis Kellis High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
description	Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants.
format	article
author	Xinchen Wang Liang He Sarah M. Goggin Alham Saadat Li Wang Nasa Sinnott-Armstrong Melina Claussnitzer Manolis Kellis
author_facet	Xinchen Wang Liang He Sarah M. Goggin Alham Saadat Li Wang Nasa Sinnott-Armstrong Melina Claussnitzer Manolis Kellis
author_sort	Xinchen Wang
title	High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
title_short	High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
title_full	High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
title_fullStr	High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
title_full_unstemmed	High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
title_sort	high-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1
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High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

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