High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human
Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants...
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Main Authors: | Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
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Subjects: | |
Online Access: | https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1 |
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