Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Here, the authors analyse a cohort of CML samples with genomic technologies and find that at least one driver alteration is associated with progression and worse...
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2021
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oai:doaj.org-article:b8463e0b7aef42f9abaf389f4f41e7bd2021-12-02T16:50:35ZClonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia10.1038/s41467-021-23097-w2041-1723https://doaj.org/article/b8463e0b7aef42f9abaf389f4f41e7bd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23097-whttps://doaj.org/toc/2041-1723In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Here, the authors analyse a cohort of CML samples with genomic technologies and find that at least one driver alteration is associated with progression and worse prognosis.Yotaro OchiKenichi YoshidaYing-Jung HuangMing-Chung KuoYasuhito NannyaKo SasakiKinuko MitaniNoriko HosoyaNobuhiro HiramotoTakayuki IshikawaSusan BranfordNaranie ShanmuganathanKazuma OhyashikiNaoto TakahashiTomoiku TakakuShun TsuchiyaNobuhiro KanemuraNobuhiko NakamuraYasunori UedaSatoshi YoshiharaRabindranath BeraYusuke ShiozawaLanying ZhaoJune TakedaYosaku WatataniRurika OkudaHideki MakishimaYuichi ShiraishiKenichi ChibaHiroko TanakaMasashi SanadaAkifumi Takaori-KondoSatoru MiyanoSeishi OgawaLee-Yung ShihNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Yotaro Ochi Kenichi Yoshida Ying-Jung Huang Ming-Chung Kuo Yasuhito Nannya Ko Sasaki Kinuko Mitani Noriko Hosoya Nobuhiro Hiramoto Takayuki Ishikawa Susan Branford Naranie Shanmuganathan Kazuma Ohyashiki Naoto Takahashi Tomoiku Takaku Shun Tsuchiya Nobuhiro Kanemura Nobuhiko Nakamura Yasunori Ueda Satoshi Yoshihara Rabindranath Bera Yusuke Shiozawa Lanying Zhao June Takeda Yosaku Watatani Rurika Okuda Hideki Makishima Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Masashi Sanada Akifumi Takaori-Kondo Satoru Miyano Seishi Ogawa Lee-Yung Shih Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| description |
In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Here, the authors analyse a cohort of CML samples with genomic technologies and find that at least one driver alteration is associated with progression and worse prognosis. |
| format |
article |
| author |
Yotaro Ochi Kenichi Yoshida Ying-Jung Huang Ming-Chung Kuo Yasuhito Nannya Ko Sasaki Kinuko Mitani Noriko Hosoya Nobuhiro Hiramoto Takayuki Ishikawa Susan Branford Naranie Shanmuganathan Kazuma Ohyashiki Naoto Takahashi Tomoiku Takaku Shun Tsuchiya Nobuhiro Kanemura Nobuhiko Nakamura Yasunori Ueda Satoshi Yoshihara Rabindranath Bera Yusuke Shiozawa Lanying Zhao June Takeda Yosaku Watatani Rurika Okuda Hideki Makishima Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Masashi Sanada Akifumi Takaori-Kondo Satoru Miyano Seishi Ogawa Lee-Yung Shih |
| author_facet |
Yotaro Ochi Kenichi Yoshida Ying-Jung Huang Ming-Chung Kuo Yasuhito Nannya Ko Sasaki Kinuko Mitani Noriko Hosoya Nobuhiro Hiramoto Takayuki Ishikawa Susan Branford Naranie Shanmuganathan Kazuma Ohyashiki Naoto Takahashi Tomoiku Takaku Shun Tsuchiya Nobuhiro Kanemura Nobuhiko Nakamura Yasunori Ueda Satoshi Yoshihara Rabindranath Bera Yusuke Shiozawa Lanying Zhao June Takeda Yosaku Watatani Rurika Okuda Hideki Makishima Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Masashi Sanada Akifumi Takaori-Kondo Satoru Miyano Seishi Ogawa Lee-Yung Shih |
| author_sort |
Yotaro Ochi |
| title |
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| title_short |
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| title_full |
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| title_fullStr |
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| title_full_unstemmed |
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| title_sort |
clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b8463e0b7aef42f9abaf389f4f41e7bd |
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