Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations

Abstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing hig...

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Autores principales:	Sophie Köndgen, Sebastien Calvignac-Spencer, Kim Grützmacher, Verena Keil, Kerstin Mätz-Rensing, Kathrin Nowak, Sonja Metzger, John Kiyang, Antina Lübke-Becker, Tobias Deschner, Roman M. Wittig, Felix Lankester, Fabian H. Leendertz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b84705b079a0487baf1e4833b465abfd
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spelling	oai:doaj.org-article:b84705b079a0487baf1e4833b465abfd2021-12-02T15:05:01ZEvidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations10.1038/s41598-017-14769-z2045-2322https://doaj.org/article/b84705b079a0487baf1e4833b465abfd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14769-zhttps://doaj.org/toc/2045-2322Abstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because – in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes.Sophie KöndgenSebastien Calvignac-SpencerKim GrützmacherVerena KeilKerstin Mätz-RensingKathrin NowakSonja MetzgerJohn KiyangAntina Lübke-BeckerTobias DeschnerRoman M. WittigFelix LankesterFabian H. LeendertzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
description	Abstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because – in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes.
format	article
author	Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz
author_facet	Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz
author_sort	Sophie Köndgen
title	Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
title_short	Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
title_full	Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
title_fullStr	Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
title_full_unstemmed	Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
title_sort	evidence for human streptococcus pneumoniae in wild and captive chimpanzees: a potential threat to wild populations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b84705b079a0487baf1e4833b465abfd
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Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations

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