LECTINS IN ANTI-CANCER STRATEGIES

The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjug...

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Autores principales:	M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, M. S. Afanasiev, S. S. Afanasiev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	malignant tumors receptor lectins glycoconjugates adjuvants cell targeting dendritic cells macrophages m-cells nk-cells cell subpopulations innate immunity anticancer therapy anticancer v accines Science Q
Acceso en línea:	https://doaj.org/article/b848644ad4744ae1a6a8b0fa3f45c915
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spelling	oai:doaj.org-article:b848644ad4744ae1a6a8b0fa3f45c9152021-11-23T06:14:40ZLECTINS IN ANTI-CANCER STRATEGIES2541-94202587-959610.29413/ABS.2018-3.4.11https://doaj.org/article/b848644ad4744ae1a6a8b0fa3f45c9152018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/652https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjugate pattern) strategies, approaches and tactic variants in study and development of anticancer treatments, principle variants of therapy, possible vaccines in 35 cases of blood connected tumors (leukemia, lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal compartments, pancreas, liver, kidneys, others) and cancer cell lines are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to adequate glycoconjugate patterns as well as influence distribution of co-functioning lectins and antigens CD between populations and subpopulations of antigen-presented cells (dendritic cells cDC, mDC, moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells play key role for choice and development of anticancer complex procedures increasing innate and innate-coupled immune responses. Prospects of (receptor lectin)-dependent intercellular communications and targeting glycoconjugate constructions into innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed.M. V. LakhtinV. M. LakhtinV. A. AleshkinM. S. AfanasievS. S. AfanasievScientific Сentre for Family Health and Human Reproduction Problemsarticlemalignant tumorsreceptor lectinsglycoconjugatesadjuvantscell targetingdendritic cellsmacrophagesm-cellsnk-cellscell subpopulationsinnate immunityanticancer therapyanticancer v accinesScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 69-77 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	malignant tumors receptor lectins glycoconjugates adjuvants cell targeting dendritic cells macrophages m-cells nk-cells cell subpopulations innate immunity anticancer therapy anticancer v accines Science Q
spellingShingle	malignant tumors receptor lectins glycoconjugates adjuvants cell targeting dendritic cells macrophages m-cells nk-cells cell subpopulations innate immunity anticancer therapy anticancer v accines Science Q M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev LECTINS IN ANTI-CANCER STRATEGIES
description	The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjugate pattern) strategies, approaches and tactic variants in study and development of anticancer treatments, principle variants of therapy, possible vaccines in 35 cases of blood connected tumors (leukemia, lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal compartments, pancreas, liver, kidneys, others) and cancer cell lines are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to adequate glycoconjugate patterns as well as influence distribution of co-functioning lectins and antigens CD between populations and subpopulations of antigen-presented cells (dendritic cells cDC, mDC, moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells play key role for choice and development of anticancer complex procedures increasing innate and innate-coupled immune responses. Prospects of (receptor lectin)-dependent intercellular communications and targeting glycoconjugate constructions into innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed.
format	article
author	M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev
author_facet	M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev
author_sort	M. V. Lakhtin
title	LECTINS IN ANTI-CANCER STRATEGIES
title_short	LECTINS IN ANTI-CANCER STRATEGIES
title_full	LECTINS IN ANTI-CANCER STRATEGIES
title_fullStr	LECTINS IN ANTI-CANCER STRATEGIES
title_full_unstemmed	LECTINS IN ANTI-CANCER STRATEGIES
title_sort	lectins in anti-cancer strategies
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/b848644ad4744ae1a6a8b0fa3f45c915
work_keys_str_mv	AT mvlakhtin lectinsinanticancerstrategies AT vmlakhtin lectinsinanticancerstrategies AT vaaleshkin lectinsinanticancerstrategies AT msafanasiev lectinsinanticancerstrategies AT ssafanasiev lectinsinanticancerstrategies
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LECTINS IN ANTI-CANCER STRATEGIES

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