Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma

Abstract Background Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells, the function and molecular mechanism of LINC01559 in regulating lung...

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Autores principales:	Zhuochen Zhao, Junhu Wan, Manman Guo, Zhengwu Yang, Zhuofang Li, Yangxia Wang, Liang Ming
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lung adenocarcinoma Long non-coding RNA Autophagy LINC01559 In vitro validation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/b84f5f28efde4354bc4502725bfce423
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spelling	oai:doaj.org-article:b84f5f28efde4354bc4502725bfce4232021-11-28T12:36:45ZLong non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma10.1186/s12935-021-02338-41475-2867https://doaj.org/article/b84f5f28efde4354bc4502725bfce4232021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02338-4https://doaj.org/toc/1475-2867Abstract Background Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells, the function and molecular mechanism of LINC01559 in regulating lung cancer development remain to be elucidated. Method and materials In this study, we used bioinformatics to screen out autophagy-related lncRNAs from TCGA-LUAD repository. Then the least absolute shrinkage and selection operator (LASSO) regression was applied to establish the signature of autophagy-related lncRNAs so that clinical characteristics and survival in LUAD patients be evaluated. Finally, we selected the most significant differences lncRNA, LINC01559, to verify its function in regulating LUAD progression in vitro. Results We found high expression of LINC01559 indicates lymph node metastasis and poor prognosis. Besides, LINC01559 promotes lung cancer cell proliferation and migration in vitro, by enhancing autophagy signal pathway via sponging hsa-miR-1343-3p. Conclusion We revealed a novel prognostic model based on autophagy-related lncRNAs, and provide a new therapeutic target and for patients with lung adenocarcinoma named LINC01559.Zhuochen ZhaoJunhu WanManman GuoZhengwu YangZhuofang LiYangxia WangLiang MingBMCarticleLung adenocarcinomaLong non-coding RNAAutophagyLINC01559In vitro validationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lung adenocarcinoma Long non-coding RNA Autophagy LINC01559 In vitro validation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Lung adenocarcinoma Long non-coding RNA Autophagy LINC01559 In vitro validation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Zhuochen Zhao Junhu Wan Manman Guo Zhengwu Yang Zhuofang Li Yangxia Wang Liang Ming Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
description	Abstract Background Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells, the function and molecular mechanism of LINC01559 in regulating lung cancer development remain to be elucidated. Method and materials In this study, we used bioinformatics to screen out autophagy-related lncRNAs from TCGA-LUAD repository. Then the least absolute shrinkage and selection operator (LASSO) regression was applied to establish the signature of autophagy-related lncRNAs so that clinical characteristics and survival in LUAD patients be evaluated. Finally, we selected the most significant differences lncRNA, LINC01559, to verify its function in regulating LUAD progression in vitro. Results We found high expression of LINC01559 indicates lymph node metastasis and poor prognosis. Besides, LINC01559 promotes lung cancer cell proliferation and migration in vitro, by enhancing autophagy signal pathway via sponging hsa-miR-1343-3p. Conclusion We revealed a novel prognostic model based on autophagy-related lncRNAs, and provide a new therapeutic target and for patients with lung adenocarcinoma named LINC01559.
format	article
author	Zhuochen Zhao Junhu Wan Manman Guo Zhengwu Yang Zhuofang Li Yangxia Wang Liang Ming
author_facet	Zhuochen Zhao Junhu Wan Manman Guo Zhengwu Yang Zhuofang Li Yangxia Wang Liang Ming
author_sort	Zhuochen Zhao
title	Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
title_short	Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
title_full	Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
title_fullStr	Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
title_full_unstemmed	Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
title_sort	long non-coding rna linc01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b84f5f28efde4354bc4502725bfce423
work_keys_str_mv	AT zhuochenzhao longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT junhuwan longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT manmanguo longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT zhengwuyang longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT zhuofangli longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT yangxiawang longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma AT liangming longnoncodingrnalinc01559exertsoncogenicroleviaenhancingautophagyinlungadenocarcinoma
_version_	1718407915677679616

Long non-coding RNA LINC01559 exerts oncogenic role via enhancing autophagy in lung adenocarcinoma

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