Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb

Cholinergic neurons innervate multiple layers in the main olfactory bulb but the precise circuitry of this input is not known. Here the authors show that VGLUT3+ cholinergic neurons selectively innervate deep short axon cells in specific layers and elicit robust monosynaptic GABAergic and nicotinic...

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Autores principales: Daniel T. Case, Shawn D. Burton, Jeremy Y. Gedeon, Sean-Paul G. Williams, Nathaniel N. Urban, Rebecca P. Seal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b84ff619069b4552a34c5e8a891821e9
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Sumario:Cholinergic neurons innervate multiple layers in the main olfactory bulb but the precise circuitry of this input is not known. Here the authors show that VGLUT3+ cholinergic neurons selectively innervate deep short axon cells in specific layers and elicit robust monosynaptic GABAergic and nicotinic postsynaptic currents.