Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction,...

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Autores principales:	Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b856289dee3f46f7953a233bb72c1adc
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spelling	oai:doaj.org-article:b856289dee3f46f7953a233bb72c1adc2021-12-02T16:31:04ZTargeting QKI-7 in vivo restores endothelial cell function in diabetes10.1038/s41467-020-17468-y2041-1723https://doaj.org/article/b856289dee3f46f7953a233bb72c1adc2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17468-yhttps://doaj.org/toc/2041-1723Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.Chunbo YangMagdalini EleftheriadouSophia KelainiThomas MorrisonMarta Vilà GonzálezRachel CainesNicola EdwardsAndrew YacoubKevin EdgarArya MoezAleksandar IveticAnna ZampetakiLingfang ZengFiona L. WilkinsonNoemi LoisAlan W. StittDavid J. GrieveAndriana MargaritiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunbo Yang Magdalini Eleftheriadou Sophia Kelaini Thomas Morrison Marta Vilà González Rachel Caines Nicola Edwards Andrew Yacoub Kevin Edgar Arya Moez Aleksandar Ivetic Anna Zampetaki Lingfang Zeng Fiona L. Wilkinson Noemi Lois Alan W. Stitt David J. Grieve Andriana Margariti Targeting QKI-7 in vivo restores endothelial cell function in diabetes
description	Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.
format	article
author	Chunbo Yang Magdalini Eleftheriadou Sophia Kelaini Thomas Morrison Marta Vilà González Rachel Caines Nicola Edwards Andrew Yacoub Kevin Edgar Arya Moez Aleksandar Ivetic Anna Zampetaki Lingfang Zeng Fiona L. Wilkinson Noemi Lois Alan W. Stitt David J. Grieve Andriana Margariti
author_facet	Chunbo Yang Magdalini Eleftheriadou Sophia Kelaini Thomas Morrison Marta Vilà González Rachel Caines Nicola Edwards Andrew Yacoub Kevin Edgar Arya Moez Aleksandar Ivetic Anna Zampetaki Lingfang Zeng Fiona L. Wilkinson Noemi Lois Alan W. Stitt David J. Grieve Andriana Margariti
author_sort	Chunbo Yang
title	Targeting QKI-7 in vivo restores endothelial cell function in diabetes
title_short	Targeting QKI-7 in vivo restores endothelial cell function in diabetes
title_full	Targeting QKI-7 in vivo restores endothelial cell function in diabetes
title_fullStr	Targeting QKI-7 in vivo restores endothelial cell function in diabetes
title_full_unstemmed	Targeting QKI-7 in vivo restores endothelial cell function in diabetes
title_sort	targeting qki-7 in vivo restores endothelial cell function in diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b856289dee3f46f7953a233bb72c1adc
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Targeting QKI-7 in vivo restores endothelial cell function in diabetes

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