Targeting QKI-7 in vivo restores endothelial cell function in diabetes
Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction,...
Saved in:
Main Authors: | Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/b856289dee3f46f7953a233bb72c1adc |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes
by: Chunbo Yang, et al.
Published: (2020) -
Direct reprogramming of adult cells: avoiding the pluripotent state
by: Kelaini S, et al.
Published: (2014) -
QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells.
by: Lin Jiang, et al.
Published: (2010) -
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
by: Seula Shin, et al.
Published: (2021) -
Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing
by: Lama Darbelli, et al.
Published: (2017)