Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment

This study aimed to investigate whole-brain spontaneous activities changes in patients with vascular mild cognitive impairment (VaMCI), and to evaluate the relationships between these brain alterations and their neuropsychological assessments. Thirty-one patients with VaMCI and thirty-one healthy co...

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Autores principales:	Haoyuan Li, Xiuqin Jia, Yingying Li, Xuejia Jia, Qi Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vascular mild cognitive impairment (VaMCI) amplitude of low-frequency fluctuation (ALFF) degree centrality (DC) gray matter (GM) atrophy default mode network (DMN) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/b857fa28b4664e5d871eb6328e3954e3
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spelling	oai:doaj.org-article:b857fa28b4664e5d871eb6328e3954e32021-11-25T16:59:15ZAberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment10.3390/brainsci111115342076-3425https://doaj.org/article/b857fa28b4664e5d871eb6328e3954e32021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1534https://doaj.org/toc/2076-3425This study aimed to investigate whole-brain spontaneous activities changes in patients with vascular mild cognitive impairment (VaMCI), and to evaluate the relationships between these brain alterations and their neuropsychological assessments. Thirty-one patients with VaMCI and thirty-one healthy controls (HCs) underwent structural MRI and resting-state functional MRI (rs-fMRI) and neuropsychological assessments. The functional alterations were determined by the amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC). The gray matter volume (GMV) changes were analyzed using voxel-based morphometry (VBM). Linear regression analysis was used to evaluate the relationships between the structural and functional changes of brain regions and neuropsychological assessments. The VaMCI group had significantly lower scores in the Montreal Cognitive Assessment (MoCA), and higher scores on the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD). Compared to the HCs, the VaMCI group exhibited GM atrophy in the right precentral gyrus (PreCG) and right inferior temporal gyrus (ITG). VaMCI patients further exhibited significantly decreased brain activity within the default mode network (DMN), including the bilateral precuneus (PCu), angular gyrus (AG), and medial frontal gyrus (medFG). Linear regression analysis revealed that the decreased ALFF was independently associated with lower MoCA scores, and the GM atrophy was independently associated with higher HAMD scores. The current finding suggested that aberrant spontaneous brain activity in the DMN might subserve as a potential biomarker of VaMCI, which may highlight the underlying mechanism of cognitive decline in cerebral small vessel disease.Haoyuan LiXiuqin JiaYingying LiXuejia JiaQi YangMDPI AGarticlevascular mild cognitive impairment (VaMCI)amplitude of low-frequency fluctuation (ALFF)degree centrality (DC)gray matter (GM) atrophydefault mode network (DMN)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1534, p 1534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular mild cognitive impairment (VaMCI) amplitude of low-frequency fluctuation (ALFF) degree centrality (DC) gray matter (GM) atrophy default mode network (DMN) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	vascular mild cognitive impairment (VaMCI) amplitude of low-frequency fluctuation (ALFF) degree centrality (DC) gray matter (GM) atrophy default mode network (DMN) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Haoyuan Li Xiuqin Jia Yingying Li Xuejia Jia Qi Yang Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
description	This study aimed to investigate whole-brain spontaneous activities changes in patients with vascular mild cognitive impairment (VaMCI), and to evaluate the relationships between these brain alterations and their neuropsychological assessments. Thirty-one patients with VaMCI and thirty-one healthy controls (HCs) underwent structural MRI and resting-state functional MRI (rs-fMRI) and neuropsychological assessments. The functional alterations were determined by the amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC). The gray matter volume (GMV) changes were analyzed using voxel-based morphometry (VBM). Linear regression analysis was used to evaluate the relationships between the structural and functional changes of brain regions and neuropsychological assessments. The VaMCI group had significantly lower scores in the Montreal Cognitive Assessment (MoCA), and higher scores on the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD). Compared to the HCs, the VaMCI group exhibited GM atrophy in the right precentral gyrus (PreCG) and right inferior temporal gyrus (ITG). VaMCI patients further exhibited significantly decreased brain activity within the default mode network (DMN), including the bilateral precuneus (PCu), angular gyrus (AG), and medial frontal gyrus (medFG). Linear regression analysis revealed that the decreased ALFF was independently associated with lower MoCA scores, and the GM atrophy was independently associated with higher HAMD scores. The current finding suggested that aberrant spontaneous brain activity in the DMN might subserve as a potential biomarker of VaMCI, which may highlight the underlying mechanism of cognitive decline in cerebral small vessel disease.
format	article
author	Haoyuan Li Xiuqin Jia Yingying Li Xuejia Jia Qi Yang
author_facet	Haoyuan Li Xiuqin Jia Yingying Li Xuejia Jia Qi Yang
author_sort	Haoyuan Li
title	Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
title_short	Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
title_full	Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
title_fullStr	Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
title_full_unstemmed	Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
title_sort	aberrant amplitude of low-frequency fluctuation and degree centrality within the default mode network in patients with vascular mild cognitive impairment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b857fa28b4664e5d871eb6328e3954e3
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_version_	1718412859080179712

Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment

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