CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS

Abstract. Over recent years of studies in infantile cerebral paralysis (ICP), the changes in periventricular area are given great importance, especially, periventricular leukomalacia. An immunopathological process may define the prenatal brain damage. We performed a clinicalytogenetic and immunologi...

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Autores principales:	D. D. Gaynetdinova, L. Z. Gaysina, R. F. Khakimova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	infantile cerebral paralysis periventricular leukomalacia gemone instability tnfα immune state Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b85c34fdfcb046f1b1e09aec42d4f8ce
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spelling	oai:doaj.org-article:b85c34fdfcb046f1b1e09aec42d4f8ce2021-11-18T08:03:43ZCLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS1563-06252313-741X10.15789/1563-0625-2012-6-507-512https://doaj.org/article/b85c34fdfcb046f1b1e09aec42d4f8ce2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/609https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Over recent years of studies in infantile cerebral paralysis (ICP), the changes in periventricular area are given great importance, especially, periventricular leukomalacia. An immunopathological process may define the prenatal brain damage. We performed a clinicalytogenetic and immunological evaluation, including subpopulation analysis of lymphocytes, functional activity of phagocytes, quantitative content of TNFα in blood serum and saliva in thirty-five ICP patients (1 to 4 years old). This study has shown suppression of cellular immunity, increase in oxidation/reduction activity of neutrophils, and increased TNFα levels in peripheral blood serum and salivary fluid in cases of periventricular leukomalacia that resulted into ICP. An interrelation was revealed between the levels of genome instability and TNFα content, thus suggesting involvement of active immunopathological processes in those patients with ICP who develops periventricular leukomalacia.D. D. GaynetdinovaL. Z. GaysinaR. F. KhakimovaSPb RAACIarticleinfantile cerebral paralysisperiventricular leukomalaciagemone instabilitytnfαimmune stateImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 507-512 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	infantile cerebral paralysis periventricular leukomalacia gemone instability tnfα immune state Immunologic diseases. Allergy RC581-607
spellingShingle	infantile cerebral paralysis periventricular leukomalacia gemone instability tnfα immune state Immunologic diseases. Allergy RC581-607 D. D. Gaynetdinova L. Z. Gaysina R. F. Khakimova CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
description	Abstract. Over recent years of studies in infantile cerebral paralysis (ICP), the changes in periventricular area are given great importance, especially, periventricular leukomalacia. An immunopathological process may define the prenatal brain damage. We performed a clinicalytogenetic and immunological evaluation, including subpopulation analysis of lymphocytes, functional activity of phagocytes, quantitative content of TNFα in blood serum and saliva in thirty-five ICP patients (1 to 4 years old). This study has shown suppression of cellular immunity, increase in oxidation/reduction activity of neutrophils, and increased TNFα levels in peripheral blood serum and salivary fluid in cases of periventricular leukomalacia that resulted into ICP. An interrelation was revealed between the levels of genome instability and TNFα content, thus suggesting involvement of active immunopathological processes in those patients with ICP who develops periventricular leukomalacia.
format	article
author	D. D. Gaynetdinova L. Z. Gaysina R. F. Khakimova
author_facet	D. D. Gaynetdinova L. Z. Gaysina R. F. Khakimova
author_sort	D. D. Gaynetdinova
title	CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
title_short	CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
title_full	CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
title_fullStr	CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
title_full_unstemmed	CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS
title_sort	clinico-immunologic and cytogenetic aspects of pathogenesis in spastic infantile cerebral paralysis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b85c34fdfcb046f1b1e09aec42d4f8ce
work_keys_str_mv	AT ddgaynetdinova clinicoimmunologicandcytogeneticaspectsofpathogenesisinspasticinfantilecerebralparalysis AT lzgaysina clinicoimmunologicandcytogeneticaspectsofpathogenesisinspasticinfantilecerebralparalysis AT rfkhakimova clinicoimmunologicandcytogeneticaspectsofpathogenesisinspasticinfantilecerebralparalysis
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CLINICO-IMMUNOLOGIC AND CYTOGENETIC ASPECTS OF PATHOGENESIS IN SPASTIC INFANTILE CEREBRAL PARALYSIS

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