p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tu...

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Autores principales: Hye Yeon Choi, Hifzur R. Siddique, Mengmei Zheng, Yi Kou, Da-Wei Yeh, Tatsuya Machida, Chia-Lin Chen, Dinesh Babu Uthaya Kumar, Vasu Punj, Peleg Winer, Alejandro Pita, Linda Sher, Stanley M. Tahara, Ratna B. Ray, Chengyu Liang, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b860fba9de8448de8c15f0811ec7cae9
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Sumario:Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis.

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