p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tu...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b860fba9de8448de8c15f0811ec7cae9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b860fba9de8448de8c15f0811ec7cae9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b860fba9de8448de8c15f0811ec7cae92021-12-02T16:04:12Zp53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs10.1038/s41467-020-16616-82041-1723https://doaj.org/article/b860fba9de8448de8c15f0811ec7cae92020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16616-8https://doaj.org/toc/2041-1723Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis.Hye Yeon ChoiHifzur R. SiddiqueMengmei ZhengYi KouDa-Wei YehTatsuya MachidaChia-Lin ChenDinesh Babu Uthaya KumarVasu PunjPeleg WinerAlejandro PitaLinda SherStanley M. TaharaRatna B. RayChengyu LiangLin ChenHidekazu TsukamotoKeigo MachidaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| description |
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis. |
| format |
article |
| author |
Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida |
| author_facet |
Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida |
| author_sort |
Hye Yeon Choi |
| title |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_short |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_full |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_fullStr |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_full_unstemmed |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_sort |
p53 destabilizing protein skews asymmetric division and enhances notch activation to direct self-renewal of tics |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b860fba9de8448de8c15f0811ec7cae9 |
| work_keys_str_mv |
AT hyeyeonchoi p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT hifzurrsiddique p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT mengmeizheng p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT yikou p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT daweiyeh p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT tatsuyamachida p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT chialinchen p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT dineshbabuuthayakumar p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT vasupunj p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT pelegwiner p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT alejandropita p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT lindasher p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT stanleymtahara p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT ratnabray p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT chengyuliang p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT linchen p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT hidekazutsukamoto p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics AT keigomachida p53destabilizingproteinskewsasymmetricdivisionandenhancesnotchactivationtodirectselfrenewaloftics |
| _version_ |
1718385296459956224 |