Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors

Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors

Shraddha S Kale,1,2 Rachel A Burga,1,3 Elizabeth E Sweeney,1 Zungho Zun,4–6 Raymond W Sze,1,4–6 Anthony Tuesca,7 J Anand Subramony,7 Rohan Fernandes1,3,5,61The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, U...

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Autores principales: Kale SS, Burga RA, Sweeney EE, Zun Z, Sze RW, Tuesca A, Subramony JA, Fernandes R
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Theranostics
Prussian blue
iron oxide
MRI
photothermal therapy
cancer
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/b86232175a7e4a1cb52b571fb54ecdab
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spelling oai:doaj.org-article:b86232175a7e4a1cb52b571fb54ecdab2021-12-02T01:46:44ZComposite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors1178-2013https://doaj.org/article/b86232175a7e4a1cb52b571fb54ecdab2017-09-01T00:00:00Zhttps://www.dovepress.com/composite-iron-oxide-prussian-blue-nanoparticles-for-magnetically-guid-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shraddha S Kale,1,2 Rachel A Burga,1,3 Elizabeth E Sweeney,1 Zungho Zun,4–6 Raymond W Sze,1,4–6 Anthony Tuesca,7 J Anand Subramony,7 Rohan Fernandes1,3,5,61The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, USA; 2Department of Biomedical Engineering, George Washington University, Washington, DC, USA; 3The Institute for Biomedical Sciences, George Washington University, Washington, DC, USA; 4Division of Diagnostic Imaging and Radiology, Children’s National Health System, Washington, DC, USA; 5Department of Radiology, George Washington University, Washington, DC, USA; 6Department of Pediatrics, George Washington University, Washington, DC, USA; 7MedImmune LLC, Gaithersburg, MD, USA Abstract: Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe3O4@GdPB) as a novel theranostic agent for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe3O4@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as determined by characterizing studies performed in vitro and retain their properties in the presence of cells. Importantly, the Fe3O4@GdPB nanoparticles function as effective MRI contrast agents in vivo by increasing signal:noise ratios in T1-weighted scans of tumors and as effective PTT agents in vivo by decreasing tumor growth rates and increasing survival in an animal model of neuroblastoma. These findings demonstrate the potential of the Fe3O4@GdPB nanoparticles to function as effective theranostic agents.Keywords: theranostics, Prussian blue, iron oxide, MRI, photothermal therapy, cancerKale SSBurga RASweeney EEZun ZSze RWTuesca ASubramony JAFernandes RDove Medical PressarticleTheranosticsPrussian blueiron oxideMRIphotothermal therapycancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6413-6424 (2017)
institution DOAJ
collection DOAJ
language EN
topic Theranostics
Prussian blue
iron oxide
MRI
photothermal therapy
cancer
Medicine (General)
R5-920
spellingShingle Theranostics
Prussian blue
iron oxide
MRI
photothermal therapy
cancer
Medicine (General)
R5-920
Kale SS
Burga RA
Sweeney EE
Zun Z
Sze RW
Tuesca A
Subramony JA
Fernandes R
Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
description Shraddha S Kale,1,2 Rachel A Burga,1,3 Elizabeth E Sweeney,1 Zungho Zun,4–6 Raymond W Sze,1,4–6 Anthony Tuesca,7 J Anand Subramony,7 Rohan Fernandes1,3,5,61The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, USA; 2Department of Biomedical Engineering, George Washington University, Washington, DC, USA; 3The Institute for Biomedical Sciences, George Washington University, Washington, DC, USA; 4Division of Diagnostic Imaging and Radiology, Children’s National Health System, Washington, DC, USA; 5Department of Radiology, George Washington University, Washington, DC, USA; 6Department of Pediatrics, George Washington University, Washington, DC, USA; 7MedImmune LLC, Gaithersburg, MD, USA Abstract: Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe3O4@GdPB) as a novel theranostic agent for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe3O4@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as determined by characterizing studies performed in vitro and retain their properties in the presence of cells. Importantly, the Fe3O4@GdPB nanoparticles function as effective MRI contrast agents in vivo by increasing signal:noise ratios in T1-weighted scans of tumors and as effective PTT agents in vivo by decreasing tumor growth rates and increasing survival in an animal model of neuroblastoma. These findings demonstrate the potential of the Fe3O4@GdPB nanoparticles to function as effective theranostic agents.Keywords: theranostics, Prussian blue, iron oxide, MRI, photothermal therapy, cancer
format article
author Kale SS
Burga RA
Sweeney EE
Zun Z
Sze RW
Tuesca A
Subramony JA
Fernandes R
author_facet Kale SS
Burga RA
Sweeney EE
Zun Z
Sze RW
Tuesca A
Subramony JA
Fernandes R
author_sort Kale SS
title Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
title_short Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
title_full Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
title_fullStr Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
title_full_unstemmed Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
title_sort composite iron oxide–prussian blue nanoparticles for magnetically guided t1-weighted magnetic resonance imaging and photothermal therapy of tumors
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/b86232175a7e4a1cb52b571fb54ecdab
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