IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS

Mesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning...

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Auteur principal:	V. B. Klimovich
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	mesenchymal stem cells immunomodulation cellular therapy Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/b86856e30d5846bdb08cc4c250524e5c
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spelling	oai:doaj.org-article:b86856e30d5846bdb08cc4c250524e5c2021-11-18T08:03:43ZIMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS1563-06252313-741X10.15789/1563-0625-2014-2-107-126https://doaj.org/article/b86856e30d5846bdb08cc4c250524e5c2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/677https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning descent, immunophenotype and immunogenicity of MSC. The studies over last decade revealed an ability of MSC to function as immunomodulatory populations which may suppress innate immunity factors (dendritic cells, natural killers, complement), as well as T-helpers and cytotoxic T-lymphocytes, along with activation of regulatory T lymphocytes (Treg). Special attention is given to analysis of conflicting data about influence of MSC on functions of B-lymphocytes and plasma cells in experimental settings, both in vitro and in vivo conditions. Data presently available are insufficient to explain the controversions revealed. In future investigations, it is necessary to consider attribution of B-cells to B1a, B1b, or B2 subpopulations as well as possible presence of poorly studied regulatory B-cells. It is also important also to take into account potential heterogeneity of initial MSC populations being isolated according to previously approved protocols. (Med. Immunol., 2014, vol. 16, N 2, pp 107-126)V. B. KlimovichSPb RAACIarticlemesenchymal stem cellsimmunomodulationcellular therapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 107-126 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	mesenchymal stem cells immunomodulation cellular therapy Immunologic diseases. Allergy RC581-607
spellingShingle	mesenchymal stem cells immunomodulation cellular therapy Immunologic diseases. Allergy RC581-607 V. B. Klimovich IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
description	Mesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning descent, immunophenotype and immunogenicity of MSC. The studies over last decade revealed an ability of MSC to function as immunomodulatory populations which may suppress innate immunity factors (dendritic cells, natural killers, complement), as well as T-helpers and cytotoxic T-lymphocytes, along with activation of regulatory T lymphocytes (Treg). Special attention is given to analysis of conflicting data about influence of MSC on functions of B-lymphocytes and plasma cells in experimental settings, both in vitro and in vivo conditions. Data presently available are insufficient to explain the controversions revealed. In future investigations, it is necessary to consider attribution of B-cells to B1a, B1b, or B2 subpopulations as well as possible presence of poorly studied regulatory B-cells. It is also important also to take into account potential heterogeneity of initial MSC populations being isolated according to previously approved protocols. (Med. Immunol., 2014, vol. 16, N 2, pp 107-126)
format	article
author	V. B. Klimovich
author_facet	V. B. Klimovich
author_sort	V. B. Klimovich
title	IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
title_short	IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
title_full	IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
title_fullStr	IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
title_full_unstemmed	IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
title_sort	immunomodulatory activity of mesenchimal stromal (stem) cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b86856e30d5846bdb08cc4c250524e5c
work_keys_str_mv	AT vbklimovich immunomodulatoryactivityofmesenchimalstromalstemcells
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IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS

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