Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics

Cardiac resynchronisation therapy is a cornerstone in the treatment of advanced dyssynchronous heart failure. However, despite its widespread clinical application, precise mechanisms through which it exerts its beneficial effects remain elusive. Several studies have pointed to a metabolic component...

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Autores principales:	Christos-Konstantinos Antoniou, Panagiota Manolakou, Nikolaos Magkas, Konstantinos Konstantinou, Christina Chrysohoou, Polychronis Dilaveris, Konstantinos A Gatzoulis, Dimitrios Tousoulis
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b8688f2a57da4760a531ef114227c176
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spelling	oai:doaj.org-article:b8688f2a57da4760a531ef114227c1762021-12-04T16:01:20ZCardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics10.15420/ecr.2019.2.21758-37641758-3756https://doaj.org/article/b8688f2a57da4760a531ef114227c1762019-01-01T00:00:00Zhttps://www.ecrjournal.com/articles/cardiac-resynchronisation-therapy-and-cellular-bioenergetics-effects-beyond-chamberhttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Cardiac resynchronisation therapy is a cornerstone in the treatment of advanced dyssynchronous heart failure. However, despite its widespread clinical application, precise mechanisms through which it exerts its beneficial effects remain elusive. Several studies have pointed to a metabolic component suggesting that, both in concert with alterations in chamber mechanics and independently of them, resynchronisation reverses detrimental changes to cellular metabolism, increasing energy efficiency and metabolic reserve. These actions could partially account for the existence of responders that improve functionally but not echocardiographically. This article will attempt to summarise key components of cardiomyocyte metabolism in health and heart failure, with a focus on the dyssynchronous variant. Both chamber mechanics-related and -unrelated pathways of resynchronisation effects on bioenergetics – stemming from the ultramicroscopic level – and a possible common underlying mechanism relating mechanosensing to metabolism through the cytoskeleton will be presented. Improved insights regarding the cellular and molecular effects of resynchronisation on bioenergetics will promote our understanding of non-response, optimal device programming and lead to better patient care.Christos-Konstantinos AntoniouPanagiota ManolakouNikolaos MagkasKonstantinos KonstantinouChristina ChrysohoouPolychronis DilaverisKonstantinos A GatzoulisDimitrios TousoulisRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 1, Pp 33-44 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Christos-Konstantinos Antoniou Panagiota Manolakou Nikolaos Magkas Konstantinos Konstantinou Christina Chrysohoou Polychronis Dilaveris Konstantinos A Gatzoulis Dimitrios Tousoulis Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
description	Cardiac resynchronisation therapy is a cornerstone in the treatment of advanced dyssynchronous heart failure. However, despite its widespread clinical application, precise mechanisms through which it exerts its beneficial effects remain elusive. Several studies have pointed to a metabolic component suggesting that, both in concert with alterations in chamber mechanics and independently of them, resynchronisation reverses detrimental changes to cellular metabolism, increasing energy efficiency and metabolic reserve. These actions could partially account for the existence of responders that improve functionally but not echocardiographically. This article will attempt to summarise key components of cardiomyocyte metabolism in health and heart failure, with a focus on the dyssynchronous variant. Both chamber mechanics-related and -unrelated pathways of resynchronisation effects on bioenergetics – stemming from the ultramicroscopic level – and a possible common underlying mechanism relating mechanosensing to metabolism through the cytoskeleton will be presented. Improved insights regarding the cellular and molecular effects of resynchronisation on bioenergetics will promote our understanding of non-response, optimal device programming and lead to better patient care.
format	article
author	Christos-Konstantinos Antoniou Panagiota Manolakou Nikolaos Magkas Konstantinos Konstantinou Christina Chrysohoou Polychronis Dilaveris Konstantinos A Gatzoulis Dimitrios Tousoulis
author_facet	Christos-Konstantinos Antoniou Panagiota Manolakou Nikolaos Magkas Konstantinos Konstantinou Christina Chrysohoou Polychronis Dilaveris Konstantinos A Gatzoulis Dimitrios Tousoulis
author_sort	Christos-Konstantinos Antoniou
title	Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
title_short	Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
title_full	Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
title_fullStr	Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
title_full_unstemmed	Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics
title_sort	cardiac resynchronisation therapy and cellular bioenergetics: effects beyond chamber mechanics
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/b8688f2a57da4760a531ef114227c176
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Cardiac Resynchronisation Therapy and Cellular Bioenergetics: Effects Beyond Chamber Mechanics

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