SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

The capacity of cancer cells to migrate is intimately linked to their ability to induce metastasis. Here the authors show that the sodium channel β4 subunit regulates breast cancer cell migration via inhibition of RhoA activation, independently from its function as an auxiliary protein of the sodium...

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Autores principales:	Emeline Bon, Virginie Driffort, Frédéric Gradek, Carlos Martinez-Caceres, Monique Anchelin, Pablo Pelegrin, Maria-Luisa Cayuela, Séverine Marionneau-Lambot, Thibauld Oullier, Roseline Guibon, Gaëlle Fromont, Jorge L. Gutierrez-Pajares, Isabelle Domingo, Eric Piver, Alain Moreau, Julien Burlaud-Gaillard, Philippe G. Frank, Stéphan Chevalier, Pierre Besson, Sébastien Roger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b868edb8e4164085a3574d6fbc6f262e
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spelling	oai:doaj.org-article:b868edb8e4164085a3574d6fbc6f262e2021-12-02T17:32:08ZSCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer10.1038/ncomms136482041-1723https://doaj.org/article/b868edb8e4164085a3574d6fbc6f262e2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13648https://doaj.org/toc/2041-1723The capacity of cancer cells to migrate is intimately linked to their ability to induce metastasis. Here the authors show that the sodium channel β4 subunit regulates breast cancer cell migration via inhibition of RhoA activation, independently from its function as an auxiliary protein of the sodium channel.Emeline BonVirginie DriffortFrédéric GradekCarlos Martinez-CaceresMonique AnchelinPablo PelegrinMaria-Luisa CayuelaSéverine Marionneau-LambotThibauld OullierRoseline GuibonGaëlle FromontJorge L. Gutierrez-PajaresIsabelle DomingoEric PiverAlain MoreauJulien Burlaud-GaillardPhilippe G. FrankStéphan ChevalierPierre BessonSébastien RogerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emeline Bon Virginie Driffort Frédéric Gradek Carlos Martinez-Caceres Monique Anchelin Pablo Pelegrin Maria-Luisa Cayuela Séverine Marionneau-Lambot Thibauld Oullier Roseline Guibon Gaëlle Fromont Jorge L. Gutierrez-Pajares Isabelle Domingo Eric Piver Alain Moreau Julien Burlaud-Gaillard Philippe G. Frank Stéphan Chevalier Pierre Besson Sébastien Roger SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
description	The capacity of cancer cells to migrate is intimately linked to their ability to induce metastasis. Here the authors show that the sodium channel β4 subunit regulates breast cancer cell migration via inhibition of RhoA activation, independently from its function as an auxiliary protein of the sodium channel.
format	article
author	Emeline Bon Virginie Driffort Frédéric Gradek Carlos Martinez-Caceres Monique Anchelin Pablo Pelegrin Maria-Luisa Cayuela Séverine Marionneau-Lambot Thibauld Oullier Roseline Guibon Gaëlle Fromont Jorge L. Gutierrez-Pajares Isabelle Domingo Eric Piver Alain Moreau Julien Burlaud-Gaillard Philippe G. Frank Stéphan Chevalier Pierre Besson Sébastien Roger
author_facet	Emeline Bon Virginie Driffort Frédéric Gradek Carlos Martinez-Caceres Monique Anchelin Pablo Pelegrin Maria-Luisa Cayuela Séverine Marionneau-Lambot Thibauld Oullier Roseline Guibon Gaëlle Fromont Jorge L. Gutierrez-Pajares Isabelle Domingo Eric Piver Alain Moreau Julien Burlaud-Gaillard Philippe G. Frank Stéphan Chevalier Pierre Besson Sébastien Roger
author_sort	Emeline Bon
title	SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
title_short	SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
title_full	SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
title_fullStr	SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
title_full_unstemmed	SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
title_sort	scn4b acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b868edb8e4164085a3574d6fbc6f262e
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SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

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