Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat

Introduction: Urinary tract infection (UTI) is a common bacterial infection and usually requires antibiotics for treatment. But the antibiotic resistance is always a serious concern. So, developing some alternative medication strategies such as herbal medicine is an extreme need. Several studies hav...

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Autores principales:	Fateme Guitynavard, Hedieh Moradi Tabriz, Ali Samadi, Seyed Aboozar Jazayeri, Mahdi Fasihi-Ramandi, Akram Mirzaei, Mahdi Khoshchehreh, Vahid Abedi Yarandi
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2021
Materias:	cystitis urinary tract infection cornus mas animal model Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/b8694cbda47947cd9cd2dc88fd156555
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spelling	oai:doaj.org-article:b8694cbda47947cd9cd2dc88fd1565552021-11-30T07:18:39ZInvestigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat10.22034/TRU.2021.292974.10712717-042Xhttps://doaj.org/article/b8694cbda47947cd9cd2dc88fd1565552021-07-01T00:00:00Zhttps://www.transresurology.com/article_132945.htmlhttps://doaj.org/toc/2717-042XIntroduction: Urinary tract infection (UTI) is a common bacterial infection and usually requires antibiotics for treatment. But the antibiotic resistance is always a serious concern. So, developing some alternative medication strategies such as herbal medicine is an extreme need. Several studies have confirmed the prophylactic and also therapeutic effects of a variety of anthocyanin-containing berries for UTIs. Cornus mas which is native to Southern Europe and Southwestern Asia is also rich in anthocyanin but its effect on UTI has been not yet studied. This study aims to evaluate the effect of Cornu's mas extract in treating UTI in rat models. Methods: After inducing UTI in 18 Wistar rats, they were sub-grouped into three groups: control group, nitrofurantoin treated group (case I) and Cornus mas treated group (case II). After seven days of treatment, the UTI indicators like fever, microscopic analysis of urine, and pathological examination of the bladder were investigated. Results: Actually, UTI indicators were resolved after treatment in both treated groups (nitrofurantoin and case II). Comparison of the results between the control group and the other three groups confirmed the development of UTI in the rat model. Clinical, laboratory, and pathologic results proposed that the Cornus mas extract effects in treating UTI are not inferior to that of nitrofurantoin. Conclusion: In addition to its anti-inflammatory effects, Cornu's mas extract can be a gifted potential substitute for antibiotics in treating UTI in rat models.Fateme GuitynavardHedieh Moradi TabrizAli Samadi Seyed Aboozar JazayeriMahdi Fasihi-RamandiAkram Mirzaei Mahdi KhoshchehrehVahid Abedi YarandiUrology Research Centerarticlecystitisurinary tract infectioncornus masanimal modelDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 3, Iss 2, Pp 67-73 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystitis urinary tract infection cornus mas animal model Diseases of the genitourinary system. Urology RC870-923
spellingShingle	cystitis urinary tract infection cornus mas animal model Diseases of the genitourinary system. Urology RC870-923 Fateme Guitynavard Hedieh Moradi Tabriz Ali Samadi Seyed Aboozar Jazayeri Mahdi Fasihi-Ramandi Akram Mirzaei Mahdi Khoshchehreh Vahid Abedi Yarandi Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
description	Introduction: Urinary tract infection (UTI) is a common bacterial infection and usually requires antibiotics for treatment. But the antibiotic resistance is always a serious concern. So, developing some alternative medication strategies such as herbal medicine is an extreme need. Several studies have confirmed the prophylactic and also therapeutic effects of a variety of anthocyanin-containing berries for UTIs. Cornus mas which is native to Southern Europe and Southwestern Asia is also rich in anthocyanin but its effect on UTI has been not yet studied. This study aims to evaluate the effect of Cornu's mas extract in treating UTI in rat models. Methods: After inducing UTI in 18 Wistar rats, they were sub-grouped into three groups: control group, nitrofurantoin treated group (case I) and Cornus mas treated group (case II). After seven days of treatment, the UTI indicators like fever, microscopic analysis of urine, and pathological examination of the bladder were investigated. Results: Actually, UTI indicators were resolved after treatment in both treated groups (nitrofurantoin and case II). Comparison of the results between the control group and the other three groups confirmed the development of UTI in the rat model. Clinical, laboratory, and pathologic results proposed that the Cornus mas extract effects in treating UTI are not inferior to that of nitrofurantoin. Conclusion: In addition to its anti-inflammatory effects, Cornu's mas extract can be a gifted potential substitute for antibiotics in treating UTI in rat models.
format	article
author	Fateme Guitynavard Hedieh Moradi Tabriz Ali Samadi Seyed Aboozar Jazayeri Mahdi Fasihi-Ramandi Akram Mirzaei Mahdi Khoshchehreh Vahid Abedi Yarandi
author_facet	Fateme Guitynavard Hedieh Moradi Tabriz Ali Samadi Seyed Aboozar Jazayeri Mahdi Fasihi-Ramandi Akram Mirzaei Mahdi Khoshchehreh Vahid Abedi Yarandi
author_sort	Fateme Guitynavard
title	Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
title_short	Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
title_full	Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
title_fullStr	Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
title_full_unstemmed	Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat
title_sort	investigating the anti-urinary tract infection effect of cornu's mas extract in the rat
publisher	Urology Research Center
publishDate	2021
url	https://doaj.org/article/b8694cbda47947cd9cd2dc88fd156555
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Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat

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