The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C.

The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C.

<h4>Background</h4>In mouse models, natural killer (NK) cells have been shown to exert anti-fibrotic activity via killing of activated hepatic stellate cells (HSC). Chemokines and chemokine receptors critically modulate hepatic recruitment of NK cells. In hepatitis C, the chemokine recep...

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Main Authors: Marianne Eisenhardt, Andreas Glässner, Benjamin Krämer, Christian Körner, Bernhard Sibbing, Pavlos Kokordelis, Hans Dieter Nischalke, Tilman Sauerbruch, Ulrich Spengler, Jacob Nattermann
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/b869fb675531404b925b73123d54a2a4
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