Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripod ligand and show that the binding is dynamic.

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Autores principales:	Wenting Liu, Yi-Fang Zhong, Liu-Yi Liu, Chu-Tong Shen, Wenjuan Zeng, Fuyi Wang, Danzhou Yang, Zong-Wan Mao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b86abdb8dcab48ffa099caa1ceb4eeee
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spelling	oai:doaj.org-article:b86abdb8dcab48ffa099caa1ceb4eeee2021-12-02T15:34:03ZSolution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding10.1038/s41467-018-05810-42041-1723https://doaj.org/article/b86abdb8dcab48ffa099caa1ceb4eeee2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05810-4https://doaj.org/toc/2041-1723DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripod ligand and show that the binding is dynamic.Wenting LiuYi-Fang ZhongLiu-Yi LiuChu-Tong ShenWenjuan ZengFuyi WangDanzhou YangZong-Wan MaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenting Liu Yi-Fang Zhong Liu-Yi Liu Chu-Tong Shen Wenjuan Zeng Fuyi Wang Danzhou Yang Zong-Wan Mao Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
description	DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripod ligand and show that the binding is dynamic.
format	article
author	Wenting Liu Yi-Fang Zhong Liu-Yi Liu Chu-Tong Shen Wenjuan Zeng Fuyi Wang Danzhou Yang Zong-Wan Mao
author_facet	Wenting Liu Yi-Fang Zhong Liu-Yi Liu Chu-Tong Shen Wenjuan Zeng Fuyi Wang Danzhou Yang Zong-Wan Mao
author_sort	Wenting Liu
title	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
title_short	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
title_full	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
title_fullStr	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
title_full_unstemmed	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
title_sort	solution structures of multiple g-quadruplex complexes induced by a platinum(ii)-based tripod reveal dynamic binding
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b86abdb8dcab48ffa099caa1ceb4eeee
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Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

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