Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease

Objective: This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. Methods: Blood samples were collected from 56 patients diag...

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Autores principales:	Jin-Ming Cen, Jie Cheng, Qing-Yuan Xiong, Bai-Qiang Mei, Wei-Biao Cai, Xi-Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b878dae196774e59854f66715fca6119
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spelling	oai:doaj.org-article:b878dae196774e59854f66715fca61192021-12-02T16:02:57ZStudy on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease2095-882X10.1016/j.cdtm.2015.02.009https://doaj.org/article/b878dae196774e59854f66715fca61192015-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000109https://doaj.org/toc/2095-882XObjective: This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. Methods: Blood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People's Hospital of Foshan and 34 healthy subjects from February 2013 to January 2014. We measured the concentration of plasma Lp-PLA2 and determined the levels of total cholesterol (Tch), triglyceride (TG), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), lipoprotein a (Lp(a)), glucose (Glu), and high-sensitivity C-reactive protein (hs-CRP). The concentration of plasma Lp-PLA2 in the healthy control group and each subgroup of CHD patients were compared and analyzed for correlations of plasma Lp-PLA2 between the patients in different CHD subgroups and several laboratory indicators. Results: The concentration of plasma Lp-PLA2 in each subgroup of CHD was significantly higher than in the control group (P < 0.05). The concentration of Lp-PLA2 in the unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were significantly higher than in the stable angina pectoris (SAP) group (P < 0.05), and the concentration of plasma Lp-PLA2 in the AMI group was significantly higher than in the UAP group (P < 0.05). The concentration of plasma Lp-PLA2 in the CHD group merely showed a positive correlation (r = 0.493, P < 0.05) with the hs-CRP group, but the levels of Tch, TG, Apo-A1, Apo-B, HDL-c, LDL-c, Lp(a) and Glu did not. Conclusions: The concentration of plasma Lp-PLA2 in patients with CHD was higher than that in the control group. The concentration of plasma Lp-PLA2 in the subgroups of CHD patients varied greatly from each other. The inflammatory response of atherosclerosis might be resulted from the synergy of plasma Lp-PLA2 and hs-CRP. Keywords: Coronary heart disease, Plasma lipoprotein-associated phospholipase A2, AtherosclerosisJin-Ming CenJie ChengQing-Yuan XiongBai-Qiang MeiWei-Biao CaiXi-Li YangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 2, Pp 105-109 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jin-Ming Cen Jie Cheng Qing-Yuan Xiong Bai-Qiang Mei Wei-Biao Cai Xi-Li Yang Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
description	Objective: This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. Methods: Blood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People's Hospital of Foshan and 34 healthy subjects from February 2013 to January 2014. We measured the concentration of plasma Lp-PLA2 and determined the levels of total cholesterol (Tch), triglyceride (TG), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), lipoprotein a (Lp(a)), glucose (Glu), and high-sensitivity C-reactive protein (hs-CRP). The concentration of plasma Lp-PLA2 in the healthy control group and each subgroup of CHD patients were compared and analyzed for correlations of plasma Lp-PLA2 between the patients in different CHD subgroups and several laboratory indicators. Results: The concentration of plasma Lp-PLA2 in each subgroup of CHD was significantly higher than in the control group (P < 0.05). The concentration of Lp-PLA2 in the unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were significantly higher than in the stable angina pectoris (SAP) group (P < 0.05), and the concentration of plasma Lp-PLA2 in the AMI group was significantly higher than in the UAP group (P < 0.05). The concentration of plasma Lp-PLA2 in the CHD group merely showed a positive correlation (r = 0.493, P < 0.05) with the hs-CRP group, but the levels of Tch, TG, Apo-A1, Apo-B, HDL-c, LDL-c, Lp(a) and Glu did not. Conclusions: The concentration of plasma Lp-PLA2 in patients with CHD was higher than that in the control group. The concentration of plasma Lp-PLA2 in the subgroups of CHD patients varied greatly from each other. The inflammatory response of atherosclerosis might be resulted from the synergy of plasma Lp-PLA2 and hs-CRP. Keywords: Coronary heart disease, Plasma lipoprotein-associated phospholipase A2, Atherosclerosis
format	article
author	Jin-Ming Cen Jie Cheng Qing-Yuan Xiong Bai-Qiang Mei Wei-Biao Cai Xi-Li Yang
author_facet	Jin-Ming Cen Jie Cheng Qing-Yuan Xiong Bai-Qiang Mei Wei-Biao Cai Xi-Li Yang
author_sort	Jin-Ming Cen
title	Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
title_short	Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
title_full	Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
title_fullStr	Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
title_full_unstemmed	Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease
title_sort	study on the correlation between the concentration of plasma lipoprotein-associated phospholipase a2 and coronary heart disease
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/b878dae196774e59854f66715fca6119
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Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease

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