CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION

The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific...

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Autor principal:	G. N. Leonova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	tbev strains pathogenicity specific igg Science Q
Acceso en línea:	https://doaj.org/article/b8791441a3954d7b962715c8c7abdbab
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spelling	oai:doaj.org-article:b8791441a3954d7b962715c8c7abdbab2021-11-23T06:14:41ZCHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION2541-94202587-959610.29413/ABS.2018-3.4.7https://doaj.org/article/b8791441a3954d7b962715c8c7abdbab2018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/648https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific antibodies in persons vaccinated against TBE.The aim of the present study is to show the differences in biological properties on the model of two strains of Far Eastern TBEV subtype belonging to different clusters and to substantiate the need for a personalized approach to the vaccine prophylaxis of tick-borne encephalitis.Results. Two strains of TBEV were used in the studies. On the basis of full genome sequencing the Dal’negorsk strain (FJ402886, GenBank) is referred to the typical representative of Sofjin-like, and Primorye-437 (JQ825162, GenBank) – to Oshima-like TBEV strains of the Far Eastern subtype.The experiment shows the levels of specific antibodies capable of neutralizing virulence strains of tick- borne encephalitis virus. Low antibody titers (1:100 and 1:400) can neutralize only a low dose of a non-virulent strain of tick-borne encephalitis virus. Reliable protection against the disease of people infected with virulent strains of the TBEV can provide only a high level of specific antibodies.Conclusion. If the level of specific antibodies of IgG is 1:400 or lower, the vaccination course should be continued, at a titer of antibodies above 1:400, revaccination can be postponed subject to annual monitoring of specific immunity parameters in the pre-epidemic TBE season.G. N. LeonovaScientific Сentre for Family Health and Human Reproduction Problemsarticletbev strainspathogenicityspecific iggScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 42-46 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	tbev strains pathogenicity specific igg Science Q
spellingShingle	tbev strains pathogenicity specific igg Science Q G. N. Leonova CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
description	The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific antibodies in persons vaccinated against TBE.The aim of the present study is to show the differences in biological properties on the model of two strains of Far Eastern TBEV subtype belonging to different clusters and to substantiate the need for a personalized approach to the vaccine prophylaxis of tick-borne encephalitis.Results. Two strains of TBEV were used in the studies. On the basis of full genome sequencing the Dal’negorsk strain (FJ402886, GenBank) is referred to the typical representative of Sofjin-like, and Primorye-437 (JQ825162, GenBank) – to Oshima-like TBEV strains of the Far Eastern subtype.The experiment shows the levels of specific antibodies capable of neutralizing virulence strains of tick- borne encephalitis virus. Low antibody titers (1:100 and 1:400) can neutralize only a low dose of a non-virulent strain of tick-borne encephalitis virus. Reliable protection against the disease of people infected with virulent strains of the TBEV can provide only a high level of specific antibodies.Conclusion. If the level of specific antibodies of IgG is 1:400 or lower, the vaccination course should be continued, at a titer of antibodies above 1:400, revaccination can be postponed subject to annual monitoring of specific immunity parameters in the pre-epidemic TBE season.
format	article
author	G. N. Leonova
author_facet	G. N. Leonova
author_sort	G. N. Leonova
title	CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
title_short	CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
title_full	CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
title_fullStr	CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
title_full_unstemmed	CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
title_sort	characteristics of the far eastern population of tick-borne encephalitis virus and solving issues of specific prevention
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/b8791441a3954d7b962715c8c7abdbab
work_keys_str_mv	AT gnleonova characteristicsofthefareasternpopulationoftickborneencephalitisvirusandsolvingissuesofspecificprevention
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CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION

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