Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

Abstract Fibroblast growth factor (FGF) 21 has various functions, including glucose and lipid metabolism. This cross-sectional study aimed to investigate specific conditions that might influence the functions of FGF21. 398 men who underwent a health examination were enrolled in this study. Physical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaori Nakanishi, Chisaki Ishibashi, Seiko Ide, Ryohei Yamamoto, Makoto Nishida, Izumi Nagatomo, Toshiki Moriyama, Keiko Yamauchi-Takihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b879cec8391740e9a963e2a648a2abe6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b879cec8391740e9a963e2a648a2abe6
record_format	dspace
spelling	oai:doaj.org-article:b879cec8391740e9a963e2a648a2abe62021-11-21T12:18:02ZSerum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects10.1038/s41598-021-02075-82045-2322https://doaj.org/article/b879cec8391740e9a963e2a648a2abe62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02075-8https://doaj.org/toc/2045-2322Abstract Fibroblast growth factor (FGF) 21 has various functions, including glucose and lipid metabolism. This cross-sectional study aimed to investigate specific conditions that might influence the functions of FGF21. 398 men who underwent a health examination were enrolled in this study. Physical and biochemical parameters and information on several lifestyle behaviors were obtained from all subjects. FGF21 levels correlated with age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GTP), uric acid, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and HbA1c. Moreover, FGF21 levels were significantly associated with lifestyle behaviors, including smoking status and breakfast and alcohol consumption frequency. Multivariable regression analysis showed that age, ALT, γ-GTP, smoking status, and breakfast and alcohol consumption frequency were independent variables for FGF21 levels. Assessment among the non-obese and obese groups showed that FGF21 levels correlated with WC, SBP, and TC only in the non-obese group. Thus, serum FGF21 levels were affected by several factors, including lifestyle behaviors, age, and liver function. To assess the functions of FGF21 in individuals, considering these factors would be essential.Kaori NakanishiChisaki IshibashiSeiko IdeRyohei YamamotoMakoto NishidaIzumi NagatomoToshiki MoriyamaKeiko Yamauchi-TakiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaori Nakanishi Chisaki Ishibashi Seiko Ide Ryohei Yamamoto Makoto Nishida Izumi Nagatomo Toshiki Moriyama Keiko Yamauchi-Takihara Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
description	Abstract Fibroblast growth factor (FGF) 21 has various functions, including glucose and lipid metabolism. This cross-sectional study aimed to investigate specific conditions that might influence the functions of FGF21. 398 men who underwent a health examination were enrolled in this study. Physical and biochemical parameters and information on several lifestyle behaviors were obtained from all subjects. FGF21 levels correlated with age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GTP), uric acid, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and HbA1c. Moreover, FGF21 levels were significantly associated with lifestyle behaviors, including smoking status and breakfast and alcohol consumption frequency. Multivariable regression analysis showed that age, ALT, γ-GTP, smoking status, and breakfast and alcohol consumption frequency were independent variables for FGF21 levels. Assessment among the non-obese and obese groups showed that FGF21 levels correlated with WC, SBP, and TC only in the non-obese group. Thus, serum FGF21 levels were affected by several factors, including lifestyle behaviors, age, and liver function. To assess the functions of FGF21 in individuals, considering these factors would be essential.
format	article
author	Kaori Nakanishi Chisaki Ishibashi Seiko Ide Ryohei Yamamoto Makoto Nishida Izumi Nagatomo Toshiki Moriyama Keiko Yamauchi-Takihara
author_facet	Kaori Nakanishi Chisaki Ishibashi Seiko Ide Ryohei Yamamoto Makoto Nishida Izumi Nagatomo Toshiki Moriyama Keiko Yamauchi-Takihara
author_sort	Kaori Nakanishi
title	Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
title_short	Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
title_full	Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
title_fullStr	Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
title_full_unstemmed	Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
title_sort	serum fgf21 levels are altered by various factors including lifestyle behaviors in male subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b879cec8391740e9a963e2a648a2abe6
work_keys_str_mv	AT kaorinakanishi serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT chisakiishibashi serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT seikoide serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT ryoheiyamamoto serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT makotonishida serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT izuminagatomo serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT toshikimoriyama serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects AT keikoyamauchitakihara serumfgf21levelsarealteredbyvariousfactorsincludinglifestylebehaviorsinmalesubjects
_version_	1718419089597136896

Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

Ejemplares similares