Models of heterogeneous dopamine signaling in an insect learning and memory center.

The Drosophila mushroom body exhibits dopamine dependent synaptic plasticity that underlies the acquisition of associative memories. Recordings of dopamine neurons in this system have identified signals related to external reinforcement such as reward and punishment. However, other factors including...

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Autores principales:	Linnie Jiang, Ashok Litwin-Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b87ab2211f9e44e1b782126f23888be5
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spelling	oai:doaj.org-article:b87ab2211f9e44e1b782126f23888be52021-12-02T19:58:06ZModels of heterogeneous dopamine signaling in an insect learning and memory center.1553-734X1553-735810.1371/journal.pcbi.1009205https://doaj.org/article/b87ab2211f9e44e1b782126f23888be52021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009205https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The Drosophila mushroom body exhibits dopamine dependent synaptic plasticity that underlies the acquisition of associative memories. Recordings of dopamine neurons in this system have identified signals related to external reinforcement such as reward and punishment. However, other factors including locomotion, novelty, reward expectation, and internal state have also recently been shown to modulate dopamine neurons. This heterogeneity is at odds with typical modeling approaches in which these neurons are assumed to encode a global, scalar error signal. How is dopamine dependent plasticity coordinated in the presence of such heterogeneity? We develop a modeling approach that infers a pattern of dopamine activity sufficient to solve defined behavioral tasks, given architectural constraints informed by knowledge of mushroom body circuitry. Model dopamine neurons exhibit diverse tuning to task parameters while nonetheless producing coherent learned behaviors. Notably, reward prediction error emerges as a mode of population activity distributed across these neurons. Our results provide a mechanistic framework that accounts for the heterogeneity of dopamine activity during learning and behavior.Linnie JiangAshok Litwin-KumarPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 8, p e1009205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Linnie Jiang Ashok Litwin-Kumar Models of heterogeneous dopamine signaling in an insect learning and memory center.
description	The Drosophila mushroom body exhibits dopamine dependent synaptic plasticity that underlies the acquisition of associative memories. Recordings of dopamine neurons in this system have identified signals related to external reinforcement such as reward and punishment. However, other factors including locomotion, novelty, reward expectation, and internal state have also recently been shown to modulate dopamine neurons. This heterogeneity is at odds with typical modeling approaches in which these neurons are assumed to encode a global, scalar error signal. How is dopamine dependent plasticity coordinated in the presence of such heterogeneity? We develop a modeling approach that infers a pattern of dopamine activity sufficient to solve defined behavioral tasks, given architectural constraints informed by knowledge of mushroom body circuitry. Model dopamine neurons exhibit diverse tuning to task parameters while nonetheless producing coherent learned behaviors. Notably, reward prediction error emerges as a mode of population activity distributed across these neurons. Our results provide a mechanistic framework that accounts for the heterogeneity of dopamine activity during learning and behavior.
format	article
author	Linnie Jiang Ashok Litwin-Kumar
author_facet	Linnie Jiang Ashok Litwin-Kumar
author_sort	Linnie Jiang
title	Models of heterogeneous dopamine signaling in an insect learning and memory center.
title_short	Models of heterogeneous dopamine signaling in an insect learning and memory center.
title_full	Models of heterogeneous dopamine signaling in an insect learning and memory center.
title_fullStr	Models of heterogeneous dopamine signaling in an insect learning and memory center.
title_full_unstemmed	Models of heterogeneous dopamine signaling in an insect learning and memory center.
title_sort	models of heterogeneous dopamine signaling in an insect learning and memory center.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b87ab2211f9e44e1b782126f23888be5
work_keys_str_mv	AT linniejiang modelsofheterogeneousdopaminesignalinginaninsectlearningandmemorycenter AT ashoklitwinkumar modelsofheterogeneousdopaminesignalinginaninsectlearningandmemorycenter
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Models of heterogeneous dopamine signaling in an insect learning and memory center.

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